Next-generation sequencing has become increasingly accessible and economical, making
genome-wide studies routine for many species, including humans, model organisms, and …

Heat-induced hormesis, ie the beneficial effect of mild heat-induced stress, increases the
average lifespan of many organisms. This effect, which depends on the heat shock factor …

Gene-based methods such as PrediXcan use expression quantitative trait loci to build tissue-
specific gene expression models when only genetic data is available. There are known sex …

Background Etiology of complex disorders, such as cataract and neurodegenerative
diseases including age-related macular degeneration (AMD), remains poorly understood …

Alzheimer's disease (AD) is a degenerative disorder that causes progressive memory and
cognitive decline. Recently, studies have reported that inhibitors of the mammalian renin …

Presenilins (PS) play a role in familial Alzheimer's disease (AD) and Notch signalling. In a
genetic screen looking for modifiers of APP but not Notch, we identified Drosophila orthologs …

Senescence is the age-related progressive deterioration of physiological processes leading
to an increased likelihood of death and is a phenomenon that occurs nearly universally …