Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling
receptor for a number of cell types, including hematopoietic stem cells, mast cells …

Growth factors and their transmembrane receptor tyrosine kinases play pivotal roles in
morphogenesis, cell fate determination and pathogenesis, including multiple stages of …

Defects in PTEN, a tumor suppressor, have been found in cancers arising in a variety of
human tissues. To elucidate the tumor-suppressive function of this gene, we have been …

Kit is a receptor tyrosine kinase (RTK) that binds stem cell factor. This receptor ligand
combination is important for normal hematopoiesis, as well as pigmentation, gut function …

Intracellular signaling is mediated by reversible posttranslational modifications (PTMs) that
include phosphorylation, ubiquitination, and acetylation, among others. In response to …

The activation of signalling pathways by ligand engagement with transmembrane receptors
is responsible for determining many aspects of cellular function and fate. While these …

Deregulation of growth factor receptor tyrosine kinases (RTKs) is linked to a large number of
malignancies. This occurs through a variety of mechanisms that result in enhanced activity of …

The adaptor protein Lnk, and the closely related proteins APS and SH2B, form a subfamily of
SH2 domain-containing proteins implicated in growth factor, cytokine, and immunoreceptor …

Events relayed via the single transmembrane receptor for erythropoietin (Epo) are essential
for the development of committed erythroid progenitor cells beyond the colony-forming unit …

Tyrosine kinase oncogenes are formed as a result of mutations that induce constitutive
kinase activity. Many of these tyrosine kinase oncogenes that are derived from genes, such …