Dopamine (DA) plays a well recognized role in a variety of physiologic functions such as
movement, cognition, mood, and reward. Consequently, many human disorders are due, in …

The abuse of illicit psychostimulants such as cocaine and methamphetamine continues to
pose significant health and societal challenges. Despite considerable efforts to develop …

Depression is a common mental disorder. The standard medical treatment is the selective
serotonin reuptake inhibitors (SSRIs). All characterized SSRIs are competitive inhibitors of …

Background and Purpose Sleep deprivation compromises learning and memory in both
humans and animals, and can be reversed by administration of modafinil, a drug promoting …

The dopamine transporter (DAT) is crucial for regulating dopamine signalling and is the
prime mediator for the rewarding and addictive effects of cocaine. As part of the …

Issues. Methamphetamine‐or amphetamine‐type stimulants are the second most frequently
used illicit drug worldwide, second only to cannabis. Behavioural treatments are efficacious …

The dopamine transporter (DAT) plays an integral role in dopamine neurotransmission
through the clearance of dopamine from the extracellular space. Dysregulation of DAT is …

Rationale and objectives Modafinil (MOD) and its R-enantiomer (R-MOD) are approved
medications for narcolepsy and other sleep disorders. They have also been used, off-label …

Background Treatment of stimulant-use disorders remains a formidable challenge, and the
dopamine transporter (DAT) remains a potential target for antagonist or agonist-like …

Modafinil (MOD) is a wakefulness-inducing compound prescribed for treatment of excessive
daytime sleepiness as a consequence of sleep disturbances such as shift work sleep …