Natural history of murine γ-herpesvirus infection

AA Nash, BM Dutia, JP Stewart… - … Transactions of the …, 2001 - royalsocietypublishing.org
Murine γ–herpesvirus 68 (MHV–68) is a natural pathogen of small rodents and insectivores
(mice, voles and shrews). The primary infection is characterized by virus replication in lung …

Dissecting the host response to a γ–herpesvirus

PC Doherty, JP Christensen… - … of the Royal …, 2001 - royalsocietypublishing.org
The murine γ–herpesvirus 68 (MHV–68) provides a unique experimental model for
dissecting immunity to large DNA viruses that persist in B lymphocytes. The analysis is …

γ-Herpesvirus latency is preferentially maintained in splenic germinal center and memory B cells

E Flaño, IJ Kim, DL Woodland… - The Journal of …, 2002 - rupress.org
The γ-herpesviruses are oncogenic B cell lymphotrophic viruses that establish life-long
latency in the host. Murine γ-herpesvirus 68 (MHV-68) infection of mice represents a unique …

Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus

SA Tibbetts, LF Van Dyk, SH Speck… - Journal of …, 2002 - Am Soc Microbiol
Despite active immune responses, gammaherpesviruses establish latency. In a related
process, these viruses also persistently replicate by using a mechanism that requires …

Selective gene expression of latent murine gammaherpesvirus 68 in B lymphocytes

S Marques, S Efstathiou, KG Smith, M Haury… - Journal of …, 2003 - Am Soc Microbiol
Intranasal infection of mice with murine gammaherpesvirus 68 (MHV-68), a virus genetically
related to the human pathogen Kaposi's sarcoma-associated herpesvirus, results in a …

Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB β2 microglobulin-deficient mice

VL Tarakanova, F Suarez, SA Tibbetts… - Journal of …, 2005 - Am Soc Microbiol
Human gammaherpesvirus infections are associated with development of
lymphoproliferative disease. Understanding of the mechanisms of gammaherpesvirus …

Disruption of the M2 gene of murine gammaherpesvirus 68 alters splenic latency following intranasal, but not intraperitoneal, inoculation

MA Jacoby, HW Virgin IV, SH Speck - Journal of virology, 2002 - Am Soc Microbiol
Infection of mice with murine gammaherpesvirus 68 (γHV68; also referred to as MHV68)
provides a tractable small-animal model with which to address the requirements for the …

The wood mouse is a natural host for Murid herpesvirus 4

K Blasdell, C McCracken, A Morris… - Journal of general …, 2003 - microbiologyresearch.org
Infection of laboratory mice by the Murid herpesvirus 4 (MHV-4) is a much studied model
system for gammaherpesvirus pathogenesis. Little, however, is known about its natural host …

Antibody-mediated control of persistent γ-herpesvirus infection

IJ Kim, E Flaño, DL Woodland… - The Journal of …, 2002 - journals.aai.org
The human γ-herpesviruses, EBV and Kaposi's sarcoma-associated herpesvirus, establish
life-long latency and can reactivate in immunocompromised individuals. T cells play an …

[HTML][HTML] Critical role of complement and viral evasion of complement in acute, persistent, and latent γ-herpesvirus infection

SB Kapadia, B Levine, SH Speck, HW Virgin - Immunity, 2002 - cell.com
Several γ-herpesviruses encode homologs of host regulators of complement activation
(RCA) proteins, suggesting that they have evolved immune evasion strategies targeting …