Pyridazinone: an important element of pharmacophore possessing broad spectrum of activity

S Dubey, PA Bhosle - Medicinal Chemistry Research, 2015 - Springer
In the last few years, the pyridazine derivatives have been found to exhibit a wide range of
pharmacological activities. A large number of research articles and patents described them …

Synthetic utility of bifunctional thiophene derivatives and antimicrobial evaluation of the newly synthesized agents

AA Abu-Hashem, KM Abu-Zied… - Monatshefte für Chemie …, 2011 - Springer
The key intermediate ethyl 2-amino-5-benzoyl-4-methylthiophene-3-carboxylate was
prepared by a Gewald reaction starting from benzoylacetone, sulfur, and ethyl cyanoacetate …

Docking simulation, synthesis and biological evaluation of novel pyridazinone containing thymol as potential antimicrobial agents

P Nagle, Y Pawar, A Sonawane, S Bhosale… - Medicinal Chemistry …, 2014 - Springer
Novel derivatives of pyridazinone containing thymol have been synthesized and evaluated
for their in vitro antimicrobial activity. Antimicrobial activities were determined using agar …

An efficient synthesis and reactions of novel indolyl-pyridazinone derivatives with expected biological activity

SA Abubshait - Molecules, 2007 - mdpi.com
Reaction of 4-anthracen-9-yl-4-oxo-but-2-enoic acid (1) with indole gave the corresponding
butanoic acid 2. Cyclocondensation of 2 with hydrazine hydrate, phenyl hydrazine …

Transition Metal-Free One-Pot Synthesis of Fused 1,4-Thiazepin-5(4H)-ones and Theoretical Study of the S–N Type Smiles Rearrangement Process

B Yang, X Tan, R Guo, S Chen, Z Zhang… - The Journal of …, 2014 - ACS Publications
A series of 1, 4-thiazepin-5 (4 H)-one derivatives were synthesized via a transition metal-free
one-pot Smiles rearrangement process at room temperature. Regioselective seven …

[PDF][PDF] Synthesis and antimicrobial activities of some new thieno and furopyrimidine derivatives

MI Hossain, MMH Bhuiyan - Journal of Scientific Research, 2009 - researchgate.net
Abstract Fused pyrimidines, 8, 9-dimethyl [1, 2, 4] triazolo [4, 3-c] thieno [3, 2-e] pyrimidine 5,
3, 8, 9-trimethyl [1, 2, 4] triazolo [4, 3-c] thieno [3, 2-e] pyrimidine 6, 4-benzylidinehydrazono …

Structure elucidation and in silico docking studies of a novel furopyrimidine antibiotics synthesized by endolithic bacterium Actinomadura sp. AL2

K Bhattacharjee, S Kumar, NR Palepu, PK Patra… - World Journal of …, 2017 - Springer
On screening of endolithic actinobacteria from a granite rock sample of Meghalaya for
antibacterial compound, a novel antibacterial compound CCp1 was isolated from the …

[PDF][PDF] Synthesis and biological evaluation of some pyridazinone derivatives

S Khaidem, S Sarveswari, R Gupta, V Vijayakumar - ChemInform, 2012 - Citeseer
ABSTRACT A series of pyridazinone derivatives were synthesized by a sequence of
reactions starting from respective aryl hydrocarbons with anhydrides in the presence of …

A transition metal-free tandem process to pyridazinopyrido [3, 2-f][1, 4] thiazepine-diones via Smiles rearrangement

X Niu, B Yang, Y Li, S Fang, Z Huang, C Xie… - Organic & Biomolecular …, 2013 - pubs.rsc.org
A transition metal-free methodology for the synthesis of pyridazinopyrido [3, 2-f][1, 4]
thiazepine-diones was studied. The construction of this tricyclic system went through a one …

[HTML][HTML] Synthesis and reactions of some novel 4-biphenyl-4-(2H)-phthalazin-1-one derivatives with an expected antimicrobial activity

SA Abubshait, RR Kassab, AH Al-Shehri… - Journal of Saudi …, 2011 - Elsevier
In this study reaction of 1-(biphenyl-4-carbonyl) benzoic acid (1) with hydrazine hydrate,
phenyl hydrazine, acetyl hydrazine and benzoyl hydrazine in boiling dry benzene gave the …