Highlights•Anti-leishmanial drugs available today pose severe side effects and are not
affordable.•Identifying suitable drug target is essential for effective drug development.•Target …

Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in
humans and domestic animals worldwide. The need for new therapeutic strategies is urgent …

The recent pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-
CoV-2) calls the whole world into a medical emergency. For tackling Coronavirus Disease …

Since HIV-1 integrase makes use of host genome machinery to accomplish the replication
process, where LEDGF/p75 (a cellular cofactor) executes in the lentiviral integration process …

The AdeABC efflux pump is an important mechanism causing multidrug resistance in
Acinetobacter baumannii, and its main component AdeB can recognize carbapenems …

The rapid increase of HIV-1 infection throughout the globe has a high demand for a superior
drug with lesser side effects. LEDGF/p75, the human Lens Epithelium-Derived Growth …

Leishmaniasis is a complex of neglected tropical diseases caused by various species of
leishmanial parasites that primarily affect the world's poorest people. A limited number of …

Highlights•Visceral leishmaniasis is a complicated infectious disease.•Emerging resistance
is one of the main complications in treatment visceral leishmaniasis.•A comprehensive …

Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers,
autoimmune disorders and infectious diseases. This is also a cornerstone approach for …

The trypanosomatid protozoa Leishmania is endemic in~ 100 countries, with infections
causing~ 2 million new cases of leishmaniasis annually. Disease symptoms can include …