Tetrazole derivatives are a prime class of heterocycles, very important to medicinal
chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide …

This short review compiles the main results of the studies in tetrazole chemistry published in
the period 2009–2016. Attention is directed to the structure, reactivity, synthetic problems …

The replacement of a carboxylic acid with a surrogate structure, or (bio)-isostere, is a
classical strategy in medicinal chemistry. The general underlying principle is that by …

Introduction Alzheimer's disease (AD) is characterized by neurotoxic immuno‐inflammation
concomitant with cytotoxic oligomerization of amyloid beta (Aβ) and tau, culminating in …

The electron density and the electrostatic potential are fundamentally related to the
molecular hamiltonian, and hence are the ultimate source of all properties in the ground …

Tetrazole cycle is a promising pharmacophore fragment frequently used in the development
of novel drugs. This moiety is a stable, practically non-metabolized bioisosteric analog of …

Lead optimization represents the tedious process of fine‐tuning lead compounds from
biologically active hits to suitable drug candidates for clinical trials. By chemically modifying …

The discovery paradigm of drugs is rapidly growing due to advances in machine learning
(ML) and artificial intelligence (AI). This review covers myriad faces of AI and ML in drug …

This Concept article summarizes recent progress in the field of hydrogen‐bonding
aminocatalysis using proline‐derived systems. The aminocatalysts available in the literature …

Tetrazoles are often used as metabolism-resistant isosteric replacements for carboxylic
acids in SAR-driven medicinal chemistry analogue syntheses. Tetrazoles have not been …