The integration of mobile genetic elements into their host chromosome influences the
immediate fate of cellular organisms and gradually shapes their evolution. Site-specific …

The importance of unusual DNA structures in the regulation of basic cellular processes is an
emerging field of research. Amongst local non-B DNA structures, G-quadruplexes (G4s) …

Histone proteins compact and organize DNA resulting in a dynamic chromatin architecture
impacting DNA accessibility and ultimately gene expression. Eukaryotic chromatin …

Microbes preserve membrane functionality under fluctuating environmental conditions by
modulating their membrane lipid composition. Although several studies have documented …

The initiation of DNA replication is typically tightly regulated by proteins that form initiation
complexes at specific sequences known as replication origins. In Archaea and Eukaryotes …

The mechanisms underpinning the replication of genomic DNA have recently been
challenged in Archaea. Indeed, the lack of origin of replication has no deleterious effect on …

One of the major mechanisms driving the evolution of all organisms is genomic
rearrangement. In hyperthermophilic Archaea of the order Thermococcales, large …

A strictly anaerobic, dissimilatory Fe (III)-reducing hyperthermophilic archaeon, designated
as strain IOH1 T, was isolated from a new deep-sea hydrothermal vent (Onnuri Vent Field) …

A number of bacterial, archaeal, and eukaryotic species are known for their resistance to
ionizing radiation. One of the challenges these species face is a potent environmental …

Thermococcales has a strong adaptability to extreme environments, which is of profound
interest in explaining how complex life forms emerge on earth. However, their gene …