Background Substance use disorder (SUD) remains a significant public health issue. A
greater understanding of how genes and environment interact to regulate phenotypes …

Abstract Purpose of Review With the advent of the genome-wide association study (GWAS),
our understanding of the genetics of addiction has made significant strides forward. Here …

Tobacco and alcohol use are leading causes of mortality that influence risk for many
complex diseases and disorders. They are heritable, and etiologically related, behaviors that …

Diverticular disease is characterized by pouches (that is, diverticulae) due to weakness in
the bowel wall, which can become infected and inflamed causing diverticulitis, with …

Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine
dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly …

Background Smoking and alcohol use have been associated with common genetic variants
in multiple loci. Rare variants within these loci hold promise in the identification of biological …

We conducted a 1000 Genomes–imputed genome-wide association study (GWAS) meta-
analysis for nicotine dependence, defined by the Fagerström Test for Nicotine Dependence …

Discovery of cancer risk variants in the sequence of the germline genome can shed light on
carcinogenesis. Here we describe gene burden association analyses, aggregating rare …

Smoking continues to be the leading preventable contributor to death worldwide. Twin
studies have suggested a significant genetic contribution underlying most smoking …

Rationale The mildly euphoric and cognitive enhancing effects of nicotine play a role in the
initiation of smoking, while dysphoria and anxiety associated with smoking cessation …