Dopamine beta‐hydroxylase (DβH) is an essential neurotransmitter‐synthesizing enzyme
that catalyzes the formation of norepinephrine (NE) from dopamine and has been …

Schizophrenia patients are behaviorally supersensitive to dopamine-like drugs such as
amphetamine or methylphenidate, meaning that patients respond to such drugs with …

The increasing prevalence of dengue virus (DENV) infection presents serious disease and
economic burdens in countries where dengue epidemics are occurring. Despite the clinical …

Positron Emission Tomography (PET) has been used for more than three decades to image
and quantify dopamine D2 receptors (D2R) in vivo with antagonist radioligands but in the …

Dopamine D 2 receptors, similar to other G-protein-coupled receptors, exist in a high-and
low-affinity state for agonists. Based upon a review of the methods for detecting D 2 receptor …

The concept of the high‐affinity state postulates that a certain subset of G‐protein‐coupled
receptors is primarily responsible for receptor signaling in the living brain. Assessing the …

Abstract Rationale (−)-Stepholidine is a tetrahydroberberine alkaloid that is known to interact
with dopamine receptors and has also been proposed as a novel antipsychotic agent. Its …

Dopamine-β-hydroxylase (DβH) deficiency is a rare genetic syndrome characterized by the
complete absence of norepinephrine in the peripheral and the central nervous system. DβH …

The features of schizophrenia are consistent with increased sensitivity to endogenous
dopamine. Animal models of schizophrenia reveal an increase in the in vitro proportion of …

The α1‐adrenergic antagonist, doxazosin, has improved cocaine use disorder (CUD)
presumably by blocking norepinephrine (NE) stimulation and reward from cocaine‐induced …