Advances and challenges in small‐molecule DNA aptamer isolation, characterization, and sensor development
Aptamers are short oligonucleotides isolated in vitro from randomized libraries that can bind
to specific molecules with high affinity, and offer a number of advantages relative to …
to specific molecules with high affinity, and offer a number of advantages relative to …
Investigations on the interface of nucleic acid aptamers and binding targets
Nucleic acid aptamers are single-stranded DNA or RNA of 20–100 nucleotides in length that
have attracted substantial scientific interest due to their ability to specifically bind to target …
have attracted substantial scientific interest due to their ability to specifically bind to target …
Sensitive small molecule aptasensing based on hybridization chain reaction and CRISPR/Cas12a using a portable 3D-printed visualizer
L Ma, D Liao, Z Zhao, J Kou, H Guo, X Xiong… - ACS …, 2023 - ACS Publications
Next-generation biosensing tools based on CRISPR/Cas have revolutionized the molecular
detection. A number of CRISPR/Cas-based biosensors have been reported for the detection …
detection. A number of CRISPR/Cas-based biosensors have been reported for the detection …
[HTML][HTML] Oligonucleotide aptamers: Recent advances in their screening, molecular conformation and therapeutic applications
X Xiao, H Li, L Zhao, Y Zhang, Z Liu - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Aptamers are single stranded oligonucleotides with specific recognition and binding ability
to target molecules, which can be obtained by Systematic Evolution of Ligands by …
to target molecules, which can be obtained by Systematic Evolution of Ligands by …
Perspective on the future role of aptamers in analytical chemistry
It has been almost 30 years since the invention of Systematic Evolution of Ligands by
Exponential Enrichment (SELEX) methodology and the description of the first aptamers. In …
Exponential Enrichment (SELEX) methodology and the description of the first aptamers. In …
Microscale thermophoresis as a powerful growing analytical technique for the investigation of biomolecular interaction and the determination of binding parameters
The in vitro panel of technologies to address biomolecular interactions are in play, however
microscale thermophoresis is continuously increasing in use to represent a key player in this …
microscale thermophoresis is continuously increasing in use to represent a key player in this …
Cross-Binding of Four Adenosine/ATP Aptamers to Caffeine, Theophylline, and Other Methylxanthines
The classical DNA aptamer for adenosine and ATP was selected twice using ATP as the
target in 1995 and 2005, respectively. In 2022, this motif appeared four more times from …
target in 1995 and 2005, respectively. In 2022, this motif appeared four more times from …
Accelerating post-SELEX aptamer engineering using exonuclease digestion
The systematic evolution of ligands by exponential enrichment (SELEX) process enables the
isolation of aptamers from random oligonucleotide libraries. However, it is generally difficult …
isolation of aptamers from random oligonucleotide libraries. However, it is generally difficult …
In silico molecular docking in DNA aptamer development
Aptamers are single-stranded DNA or RNA oligonucleotides generated by SELEX that
exhibit binding affinity and specificity against a wide variety of target molecules. Compared …
exhibit binding affinity and specificity against a wide variety of target molecules. Compared …
Aptamer‐Modified Homogeneous Catalysts, Heterogenous Nanoparticle Catalysts, and Photocatalysts: Functional “Nucleoapzymes”,“Aptananozymes”, and “ …
Y Ouyang, MP O'Hagan, B Willner… - Advanced …, 2024 - Wiley Online Library
Conjugation of aptamers to homogeneous catalysts (“nucleoapzymes”), heterogeneous
nanoparticle catalysts (“aptananozymes”), and photocatalysts (“photoaptazymes”) yields …
nanoparticle catalysts (“aptananozymes”), and photocatalysts (“photoaptazymes”) yields …