ABSTRACT Human immunodeficiency virus (HIV-1) entry into cells involves triggering of the
viral envelope glycoprotein (Env) trimer ([gp120/gp41] 3) by the primary receptor, CD4, and …

Protein structure prediction represents a significant challenge in the field of bioinformatics,
with the prediction of protein structures using backbone dihedral angles recently achieving …

The accurate germline gene assignment and assessment of somatic hypermutation in
antibodies induced by immunization or infection are important in immunological studies …

Macaques are frequently used to evaluate candidate vaccines and to study infection-
induced antibody responses, requiring an improved understanding of their naïve …

The HIV-1 envelope glycoprotein (Env) trimer is the key target for vaccines aimed at
inducing neutralizing antibodies (NAbs) against HIV-1. The clinical candidate immunogen …

During the process by which human immunodeficiency virus (HIV-1) enters cells, the
envelope glycoprotein (Env) trimer on the virion surface engages host cell receptors …

The ability of antibodies to block infections makes them highly relevant for successful
vaccine development. Through the papers described in this thesis, I attempt to characterize …

The development of a prophylactic vaccine is required for global elimination of Hepatitis C
virus (HCV), as current treatment strategies using direct acting antiviral drugs are expensive …