Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection
J Guenthoer, M Lilly, TN Starr… - Proceedings of the …, 2023 - National Acad Sciences
The antiviral benefit of antibodies can be compromised by viral escape especially for rapidly
evolving viruses. Therefore, durable, effective antibodies must be both broad and potent to …
evolving viruses. Therefore, durable, effective antibodies must be both broad and potent to …
The S2 subunit of spike encodes diverse targets for functional antibody responses to SARS-CoV-2
J Guenthoer, ME Garrett, M Lilly, DM Depierreux… - PLoS …, 2024 - journals.plos.org
The SARS-CoV-2 virus responsible for the COVID-19 global pandemic has exhibited a
striking capacity for viral evolution that drives continued evasion from vaccine and infection …
striking capacity for viral evolution that drives continued evasion from vaccine and infection …
B cell repertoire sequencing of HIV-1 pediatric elite-neutralizers identifies multiple broadly neutralizing antibody clonotypes
Introduction A limited subset of HIV-1 infected adult individuals typically after at least 2-3
years of chronic infection, develop broadly neutralizing antibodies (bnAbs), suggesting that …
years of chronic infection, develop broadly neutralizing antibodies (bnAbs), suggesting that …
Delineating the functional activity of antibodies with cross-reactivity to SARS-CoV-2, SARS-CoV-1 and related sarbecoviruses
The recurring spillover of pathogenic coronaviruses and demonstrated capacity of
sarbecoviruses, such SARS-CoV-2, to rapidly evolve in humans underscores the need to …
sarbecoviruses, such SARS-CoV-2, to rapidly evolve in humans underscores the need to …
Neonatal SHIV infection in rhesus macaques elicited heterologous HIV-1-neutralizing antibodies
B Hora, H Li, X Shen, M Martin, Y Chen, M Berry… - Cell reports, 2023 - cell.com
Infants and children infected with human immunodeficiency virus (HIV)-1 have been shown
to develop neutralizing antibodies (nAbs) against heterologous HIV-1 strains, characteristic …
to develop neutralizing antibodies (nAbs) against heterologous HIV-1 strains, characteristic …
Recapitulation of HIV-1 Neutralization Breadth in Plasma by the Combination of Two Broadly Neutralizing Antibodies from Different Lineages in the Same SHIV …
Y Gai, N Gao, Z Mou, C Yang, L Wang, W Ji… - International Journal of …, 2024 - mdpi.com
Viral infection generally induces polyclonal neutralizing antibody responses. However, how
many lineages of antibody responses can fully represent the neutralization activities in sera …
many lineages of antibody responses can fully represent the neutralization activities in sera …
Reconstruction of a polyclonal ADCC antibody repertoire from an HIV-1 non-transmitting mother
ZA Yaffe, S Ding, K Sung, V Chohan, L Marchitto… - Iscience, 2023 - cell.com
Human natural history and vaccine studies support a protective role of antibody dependent
cellular cytotoxicity (ADCC) activity against many infectious diseases. One setting where this …
cellular cytotoxicity (ADCC) activity against many infectious diseases. One setting where this …
A lentiviral vector deep mutational scanning system for studying virus evolution and escape from neutralization by antibodies and polyclonal serum
C Radford - 2023 - search.proquest.com
Viral entry proteins are critical for viral replication of enveloped viruses. These proteins allow
viruses to bind receptors on cells and accomplish membrane fusion. Since viral entry …
viruses to bind receptors on cells and accomplish membrane fusion. Since viral entry …
[图书][B] Evaluating the Impact of Antibody Epitope and Function on HIV-1 Vertical Transmission
ZA Yaffe - 2023 - search.proquest.com
Despite significant advances in scientific research and the advent of treatment and
prevention strategies over the past several decades, the HIV/AIDS pandemic continues to …
prevention strategies over the past several decades, the HIV/AIDS pandemic continues to …