The role of DNA methylation in personalized medicine for immune-related diseases

MK Gupta, H Peng, Y Li, CJ Xu - Pharmacology & Therapeutics, 2023 - Elsevier
Epigenetics functions as a bridge between host genetic & environmental factors, aiding in
human health and diseases. Many immune-related diseases, including infectious and …

Cardiac and renal comorbidities in aging people living with HIV

K McCutcheon, U Nqebelele, L Murray… - Circulation …, 2024 - Am Heart Assoc
Contemporary World Health Organization data indicates that≈ 39 million people are living
with the human immunodeficiency virus. Of these, 24 million have been reported to have …

[HTML][HTML] Epigenetic ageing accelerates before antiretroviral therapy and decelerates after viral suppression in people with HIV in Switzerland: a longitudinal study over …

IC Schoepf, A Esteban-Cantos, CW Thorball… - The Lancet Healthy …, 2023 - thelancet.com
Background Accelerated epigenetic ageing can occur in untreated HIV infection and is
partially reversible with effective antiretroviral therapy (ART). We aimed to make a long-term …

Skeletal muscle DNA methylation: Effects of exercise and HIV

CM Jankowski, IR Konigsberg, MP Wilson, J Sun… - Aging …, 2024 - Wiley Online Library
Aging, human immunodeficiency virus (HIV) infection, and antiretroviral therapy modify the
epigenetic profile and function of cells and tissues, including skeletal muscle (SkM). In some …

Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management

RJ Ellis, MJ Marquine, M Kaul, JA Fields… - Nature Reviews …, 2023 - nature.com
People living with HIV are affected by the chronic consequences of neurocognitive
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …

Excessive apoptosis of Rip1‐deficient T cells leads to premature aging

L Wang, X Zhang, H Zhang, K Lu, M Li, X Li, Y Ou… - EMBO …, 2023 - embopress.org
In mammals, the most remarkable T cell variations with aging are the shrinking of the naïve T
cell pool and the enlargement of the memory T cell pool, which are partially caused by …

[HTML][HTML] Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging

S Singh, LB Giron, MW Shaikh, S Shankaran… - Microbiome, 2024 - Springer
Background People living with HIV (PLWH), even when viral replication is controlled through
antiretroviral therapy (ART), experience persistent inflammation. This inflammation is partly …

Decreased but persistent epigenetic age acceleration is associated with changes in T-cell subsets after initiation of highly active antiretroviral therapy in persons living …

ME Sehl, EC Breen, R Shih, F Li, J Zhang… - Frontiers in …, 2024 - frontiersin.org
Introduction Persons living with HIV (PLWH) experience the early onset of age-related
illnesses, even in the setting of successful human immunodeficiency virus (HIV) suppression …

Mycobacterium tuberculosis infection and cytogenetic abnormalities among people with HIV

JB Baluku, S Namiiro, B Namanda, S Katusabe… - … /Genetic Toxicology and …, 2023 - Elsevier
Objective To compare cytogenetic abnormalities among people living with HIV (PLWH) with
and without previous exposure to Mycobacterium tuberculosis (Mtb)(both latent tuberculosis …

Transcriptomics age acceleration in prolonged treated HIV infection

F Mikaeloff, M Gelpi, A Escos, AD Knudsen, J Høgh… - Aging …, 2023 - Wiley Online Library
Biological aging in people with HIV (PWH) with prolonged successful antiretroviral therapy
(ART) is convoluted and poorly defined. Here, we aimed to investigate the transcriptomics …