Large clostridial toxins (LCTs) are a family of bacterial exotoxins that infiltrate and destroy
target cells. Members of the LCT family include Clostridioides difficile toxins TcdA and TcdB …

Abstract The BioGRID (Biological General Repository for Interaction Datasets, thebiogrid.
org) is an open‐access database resource that houses manually curated protein and …

Background & Aims Recent studies have highlighted the role of the gut microbiota and their
metabolites in non-alcoholic fatty liver disease-associated hepatocellular carcinoma …

Unbiased forward genetic screens have been extensively employed in biological research
to elucidate functional genomics. In pooled clustered regularly interspaced short palindromic …

The emergence of hypervirulent clade 2 Clostridioides difficile is associated with severe
symptoms and accounts for> 20% of global infections. TcdB is a dominant virulence factor of …

Toxin B (TcdB) is a major exotoxin responsible for diseases associated with Clostridioides
difficile infection. Its sequence variations among clinical isolates may contribute to the …

Paeniclostridium sordellii lethal toxin (TcsL) is a potent exotoxin that causes lethal toxic
shock syndrome associated with fulminant bacterial infections. TcsL belongs to the large …

Clostridioides difficile is the major worldwide cause of antibiotic-associated gastrointestinal
infection. A pathogenicity locus (PaLoc) encoding one or two homologous toxins, toxin A …

Hemorrhagic toxin (TcsH) is a major virulence factor produced by Paeniclostridium sordellii,
which is a non-negligible threat to women undergoing childbirth or abortions. Recently …

Hemorrhagic toxin (TcsH) is an important exotoxin produced by Paeniclostridium sordellii,
but the exact role of TcsH in the pathogenesis remains unclear, partly due to the lack of …