Despite considerable research efforts, it is still not clear which mechanisms underlie
neuronal cell death in neurodegenerative diseases. During the last 20 years, multiple …

Neuroinflammation, characterized by a complex interplay among innate and adaptive
immune responses within the central nervous system (CNS), is crucial in responding to …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive
dysfunction and loss of dopaminergic neurons of the substantia nigra pars compacta (SNc) …

Cortical bone loss is intricately associated with ageing and coincides with iron accumulation.
The precise role of ferroptosis, characterized by iron overload and lipid peroxidation, in …

Background Diabetic cognitive dysfunction (DCD) has attracted increased attention, but its
precise mechanism remains to be explored. Oligodendrocytes form myelin sheaths that …

Aging is a pathophysiological process that causes a gradual and permanent reduction in all
biological system functions. The phenomenon is caused by the accumulation of …

Aim Hyperlipidemia is a common comorbidity of stroke patients, elucidating the mechanism
that underlies the exacerbated ischemic brain injury after stroke with hyperlipidemia is …

Abstract Edaravone (Eda), a well-known free radical scavenger, has been reported as a
possible therapeutic agent for ischemic stroke patients' recovery. This study aimed to …

Background Cognitive dysfunction is the most severe non-motor symptom of Parkinson's
disease (PD). Our previous study revealed that hydrogen sulfide (H 2 S) ameliorates …

The necroptotic effector molecule MLKL accumulates in neurons over the lifespan of mice,
and its downregulation has the potential to improve cognition through neuroinflammation …