During animal fertilizations, each oocyte or egg must produce a proper intracellular calcium
signal for development to proceed normally. As a supplement to recent synopses of …

Fertilization calcium waves are introduced, and the evidence from which we can infer
general mechanisms of these waves is presented. The two main classes of hypotheses put …

Calcium-induced calcium release (CICR) may function widely in calcium-mediated cell
signaling, but has been most thoroughly characterized in muscle cells. In a homogenate of …

Cells possess various mechanisms for transducing external signals to intracellular
responses. The discovery of inositol 1, 4, 5-trisphosphate (IP3) as a messenger for …

1. INTRODUCTION The first measurements of cytosolic free Ca2",[Ca2"] 1, in living cells
were made with aequorin in giant muscle cells (Ridgway & Ashley, 1967) in the late 1960s …

The eggs of most or all animals are thought to be activated after fertilization by a transient
increase in free cytosolic Ca2+ concentration ([Ca2+] i). We have applied Ca2+-selective …

Reviews in Developmental Biology have covered the pathways that generate the all-
important intracellular calcium (Ca2+) signal at fertilization [Miyazaki, S., Shirakawa, H …

The transition from mature oocyte to developing embryo requires a coordinated series of
events, collectively known as egg activation. Egg activation includes changes to egg …

Cellular redox state is an important metabolic variable, influencing many aspects of cell
function like growth, apoptosis, and reductive biosynthesis. In this report, we identify NADPH …

The ER of eggs of the sea urchin Lytechinus pictus was stained by microinjecting a
saturated solution of the fluorescent dicarbocyanine DiIC18 (3)(DiI) in soybean oil; the dye …