Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair
B Marchetti, C Tirolo, F L'Episcopo, S Caniglia… - Aging cell, 2020 - Wiley Online Library
A common hallmark of age‐dependent neurodegenerative diseases is an impairment of
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …
adult neurogenesis. Wingless‐type mouse mammary tumor virus integration site (Wnt)/β …
[HTML][HTML] Vitamin D deficiency as a potential risk factor for accelerated aging, impaired hippocampal neurogenesis and cognitive decline: a role for Wnt/β-catenin …
R Gómez-Oliva, N Geribaldi-Doldán… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Vitamin D is an essential fat-soluble vitamin that participates in several homeostatic
functions in mammalian organisms. Lower levels of vitamin D are produced in the older …
functions in mammalian organisms. Lower levels of vitamin D are produced in the older …
Aging disrupts spatiotemporal regulation of germline stem cells and niche integrity
ABSTRACT A major factor driving stem cell decline is stem cell niche aging, but its
molecular mechanism remains elusive. We use the Caenorhabditis elegans distal tip cell …
molecular mechanism remains elusive. We use the Caenorhabditis elegans distal tip cell …
Robo4 inhibits gamma radiation-induced permeability of a murine microvascular endothelial cell by regulating the junctions
SY Adzraku, G Wang, C Cao, Y Bao, Y Wang… - Cellular & Molecular …, 2023 - Springer
Background Hematopoietic stem cell transplantation involves irradiation preconditioning
which causes bone marrow endothelial cell dysfunction. While much emphasis is on the …
which causes bone marrow endothelial cell dysfunction. While much emphasis is on the …
Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution
SY Adzraku, C Cao, Q Zhou, K Yuan, X Hao, Y Li… - Cell Death & …, 2024 - nature.com
Bone marrow ablation is routinely performed before hematopoietic stem cell transplantation
(HSCT). Hematopoietic stem and progenitor cells (HSPCs) require a stable bone marrow …
(HSCT). Hematopoietic stem and progenitor cells (HSPCs) require a stable bone marrow …
[HTML][HTML] Durable immunomodulatory hierarchical patch for rotator cuff repairing
L Wang, Y Liu, Z Lin, H Chen, B Liu, X Yan, T Zhu… - Bioactive Materials, 2024 - Elsevier
Degradable rotator cuff patches, followed over five years, have been observed to exhibit
high re-tear rates exceeding 50%, which is attributed to the inability of degradable polymers …
high re-tear rates exceeding 50%, which is attributed to the inability of degradable polymers …
Age-dependent structural and morphological changes of the stem cell niche disrupt spatiotemporal regulation of stem cells and drive tissue disintegration
Aging induces a progressive decline in tissue function, which has been attributed to a
decrease in stem cell function. A major factor driving this decline is the aging of the stem cell …
decrease in stem cell function. A major factor driving this decline is the aging of the stem cell …