A global view of the interplay between non-alcoholic fatty liver disease and diabetes

N Stefan, K Cusi - The lancet Diabetes & endocrinology, 2022 - thelancet.com
Non-alcoholic fatty liver disease (NAFLD) has become an epidemic, much like other non-
communicable diseases (NCDs), such as cancer, obesity, diabetes, and cardiovascular …

Why does obesity cause diabetes?

S Klein, A Gastaldelli, H Yki-Järvinen, PE Scherer - Cell metabolism, 2022 - cell.com
The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …

Metabolic (dysfunction)-associated fatty liver disease in individuals of normal weight

M Eslam, HB El-Serag, S Francque, SK Sarin… - Nature reviews …, 2022 - nature.com
Metabolic (dysfunction)-associated fatty liver disease (MAFLD) affects up to a third of the
global population; its burden has grown in parallel with rising rates of type 2 diabetes …

[HTML][HTML] An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease

E Lee, H Korf, A Vidal-Puig - Journal of hepatology, 2023 - Elsevier
Alongside the liver, white adipose tissue (WAT) is critical in regulating systemic energy
homeostasis. Although each organ has its specialised functions, they must work …

Adipose tissue fibrosis in obesity: etiology and challenges

G Marcelin, EL Gautier, K Clément - Annual review of physiology, 2022 - annualreviews.org
Obesity is a chronic and progressive process affecting whole-body energy balance and is
associated with comorbidity development. In addition to increased fat mass, obesity induces …

Chronic inflammation—A link between nonalcoholic fatty liver disease (NAFLD) and dysfunctional adipose tissue

M Petrescu, SI Vlaicu, L Ciumărnean, MV Milaciu… - Medicina, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is a new challenge in modern medicine, due to its
high prevalence in the world. The pathogenesis of NAFLD is a complex dysmetabolic …

GLP-1 agonist to treat obesity and prevent cardiovascular disease: what have we achieved so far?

MR Pedrosa, DR Franco, HW Gieremek… - Current atherosclerosis …, 2022 - Springer
Abstract Purpose of Review To discuss evidence supporting the use of glucagon-like
peptide 1 receptor agonists (GLP-1RA) to treat obesity and their role as a cardioprotective …

Towards precision medicine in non-alcoholic fatty liver disease

SM Francque - Reviews in Endocrine and Metabolic Disorders, 2023 - Springer
Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) refers to the accumulation of lipid laden
vacuoles in hepatocytes, occurring in the context of visceral adiposity, insulin resistance and …

Mesenchymal stromal cells as conductors of adipose tissue remodeling

J Cannavino, RK Gupta - Genes & Development, 2023 - genesdev.cshlp.org
Adipose tissue exhibits a remarkable capacity to expand, contract, and remodel in response
to changes in physiological and environmental conditions. Here, we describe recent …

[HTML][HTML] Mitochondrial respiration is decreased in visceral but not subcutaneous adipose tissue in obese individuals with fatty liver disease

K Pafili, S Kahl, L Mastrototaro, K Strassburger… - Journal of …, 2022 - Elsevier
Background & Aims Adipose tissue dysfunction is involved in the development of insulin
resistance and is responsible for excessive lipid delivery to other organs such as the liver …