Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in various
metabolic and cellular pathways. As an antioxidant, AKG interferes in nitrogen and ammonia …

Abstract Alpha-ketoglutarate (AKG), an endogenous intermediary metabolite in the Krebs
cycle, is a molecule involved in multiple metabolic and cellular pathways. It functions as an …

Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the
tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here …

Aging is a major risk factor for a variety of diseases, thus, translation of aging research into
practical applications is driven by the unmet need for existing clinical therapeutic options …

Background: Space radiation is one of the principal environmental factors limiting the human
tolerance for space travel, and therefore a primary risk in need of mitigation strategies to …

Parkinson's disease (PD) is a progressive movement disorder characterized by
dopaminergic (DA) neuron degeneration and the existence of Lewy bodies formed by …

Targeting molecular processes of aging will enable people to live healthier and longer lives
by preventing age-related diseases. Geroprotectors are compounds with the potential to …

The fact that men and women are living longer than they have ever done before is
something in which we can all rejoice. However, the process of ageing is associated with …

Osteoclasts (OCs) have been well-known involved in the exacerbation of bone-related
diseases. However, the role of metabolites on osteoclastogenesis has not been well …

As an intermediate of the tricarboxylic acid cycle, also known as 2‑oxoglutarate, α‑
ketoglutaric acid (AKG) plays an important role in maintaining physiological functions and …