Parkinson disease (PD) is a progressive disorder characterized by dopaminergic
neurodegeneration in the brain. The development of parkinsonism is preceded by a long …

The differential diagnosis of parkinsonian syndromes is considered one of the most
challenging in neurology and error rates in the clinical diagnosis can be high even at …

There is no well-established in vivo marker of nigral degeneration in Parkinson's disease
(PD). An ideal imaging marker would directly mirror the loss of substantia nigra …

Dopaminergic neurons of the substantia nigra selectively degenerate over the course of
Parkinson's disease. These neurons are also the most heavily pigmented cells of the brain …

This study aimed to investigate the spatiotemporal changes in neuromelanin-sensitive MRI
signal in the substantia nigra and their relation to clinical scores of disease severity in …

Objective: This study assessed whether high-resolution 7 T MRI allowed direct in vivo
visualization of nigrosomes, substructures of the substantia nigra pars compacta (SNpc) …

Background Development of reliable and accurate imaging biomarkers of dopaminergic cell
neurodegeneration is necessary to facilitate therapeutic drug trials in Parkinson's disease …

The locus coeruleus (LC), a tiny nucleus in the brainstem and the principal site of
noradrenaline synthesis, has a major role in regulating autonomic function, arousal …

Dopamine (DA) is one of the main neurotransmitters found in the central nervous system
and has a vital role in the function of dopaminergic (DArgic) neurons. A progressive loss of …

Background Parkinson's disease (PD) is a chronic neurodegenerative disorder
characterized by bradykinesia, tremor, and rigidity among other symptoms. With a 70 …