POUV is a relatively newly emerged class of POU transcription factors present in jawed
vertebrates (Gnathostomata). The function of POUV-class proteins is inextricably linked to …

Transposable elements constitute about half of the mammalian genome, and can be divided
into two classes: the class I (retrotransposons) and the class II (DNA transposons). A few …

Tumours were recently revealed to undergo a phylostratic and phenotypic shift to
unicellularity. As well, aggressive tumours are characterized by an increased proportion of …

Embryonic stem cells (ESCs) can undergo lineage-specific differentiation, giving rise to
different cell types that constitute an organism. Although roles of transcription factors and …

The monoamine neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has important
functions both in the neural system and during embryonic development in mammals. In this …

Human artificial chromosomes (HACs), including the de novo synthesized alphoidtetO-HAC,
are a powerful tool for introducing genes of interest into eukaryotic cells. HACs are …

Background SOX2 is a determinant transcription factor that governs the balance between
stemness and differentiation by influencing transcription and splicing programs. The role of …

While understanding the genetic underpinnings of osteogenesis has far-reaching
implications for skeletal diseases and evolution, a comprehensive characterization of the …

An RNA-involved phase-separation model has been proposed for transcription control. Yet,
the molecular links that connect RNA binding to the transcription machinery remain missing …

Understanding the genetic mechanisms underpinning the differentiation of osteoblasts, the
bone producing cells, has far reaching implications for skeletal diseases and evolution. To …