The oligonucleotide therapeutics field has seen remarkable progress over the last few years
with the approval of the first antisense drug and with promising developments in late stage …

The endosomal network comprises an interconnected network of membranous
compartments whose primary function is to receive, dissociate, and sort cargo that originates …

Because both the host and pathogen require iron, the innate immune response carefully
orchestrates control over iron metabolism to limit its availability during times of infection …

Protein trafficking requires coat complexes that couple recognition of sorting motifs in
transmembrane cargoes with biogenesis of transport carriers. The mechanisms of cargo …

Highlights•Actin polymerization on endosomes is primarily controlled by the regulation of the
WASH complex activity.•Endosomal actin restricts the lateral mobility of cargoes and …

Understanding the cellular uptake and intracellular trafficking of oligonucleotides provides
an important basic underpinning for the developing field of oligonucleotide-based …

Oligonucleotides manifest much promise as potential therapeutic agents. However,
understanding of how oligonucleotides function within living organisms is still rather limited …

Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neuromuscular degenerative
disorder with a poorly defined etiology. ALS patients experience motor weakness, which …

Epithelial-to-mesenchymal transition (EMT) is a transcriptionally governed process by which
cancer cells establish a front-rear polarity axis that facilitates motility and invasion. Dynamic …

RNA therapeutics (eg siRNA, oligonucleotides, mRNA, etc.) show great potential for the
treatment of a myriad of diseases. However, to reach their site of action in the cytosol or …