Osteoporosis is a widespread systemic disease characterized by a decrease in bone mass
and an imbalance of the microarchitecture of bone tissue. Experimental and clinical studies …

Age-related, non-communicable chronic inflammatory diseases represent the major 21st
century health problem. Especially in Western countries, the prevalence of non …

Senile osteoporosis (SOP) is widely regarded as one of the typical aging-related diseases
due to a decrease in bone mass and the destruction in microarchitecture. The inhibition of …

Advanced glycation end products (AGEs) have been widely reported to play an important
role in osteoporosis (OP), particularly in diabetes‑related OP. The aim of the present study …

Bone mineral density, a bone matrix parameter frequently used to predict fracture risk, is not
the only one to affect bone fragility. Other factors, including the extracellular matrix (ECM) …

Obesity and osteoporosis are two alarming health disorders prominent among middle and
old age populations, and the numbers of those affected by these two disorders are …

Diabetic cardiomyopathy (DCM) has been increasingly considered as a main cause of heart
failure and death in diabetic patients. At present, no effective treatment exists to prevent its …

Chronic obstructive pulmonary disease (COPD) is a disease of the airways and lungs due to
an enhanced inflammatory response, commonly caused by cigarette smoking. Patients with …

Bone disease is a serious complication to diabetes. Patients with type 1 diabetes (T1D) and
type 2 diabetes (T2D) suffer from an increased risk of fracture, most notably at the hip …

Pentosidine (PEN) and carboxymethyl-lysine (CML) are well-recognized advanced glycation
end products (AGEs). However, how these AGEs affect the pathophysiology of osteoporosis …