Astrocytes are specialized non-neuronal glial cells of the central nervous system,
contributing to neuronal excitability and synaptic transmission (gliotransmission). Astrocytes …

Advances in gene discovery have identified genetic variants in the solute carrier family 6
member 1 gene as a monogenic cause of neurodevelopmental disorders, including epilepsy …

Microglia are critical regulators of brain development that engulf synaptic proteins during
postnatal synapse remodeling. However, the mechanisms through which microglia sense …

Objective Patients with absence epilepsy sensitivity< 10% of their absences. The clinical
gold standard to assess absence epilepsy is a 24‐h electroencephalographic (EEG) …

Juvenile myoclonic epilepsy (JME) is a common idiopathic generalised epilepsy with
variable seizure prognosis and sex differences in disease presentation. Here, we investigate …

A potential link between GABRD encoding the δ subunit of extrasynaptic GABAA receptors
and neurodevelopmental disorders has largely been disregarded due to conflicting …

In patients suffering absence epilepsy, recurring seizures can significantly decrease their
quality of life and lead to yet untreatable comorbidities. Absence seizures are characterized …

Absence seizures are brief episodes of impaired consciousness, behavioral arrest, and
unresponsiveness, with yet-unknown neuronal mechanisms. Here we report that an awake …

Objective Mutations in γ-aminobutyric acid (GABA) transporter 1 (GAT-1)-encoding SLC6A1
have been associated with myoclonic atonic epilepsy and other phenotypes. We determined …

Levetiracetam (LEV) is an antiseizure medication (ASM) whose mechanism of action
involves the modulation of neurotransmitters release through binding to the synaptic vesicle …