The human immune system is highly variable between individuals but relatively stable over
time within a given person. Recent conceptual and technological advances have enabled …

Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Single-cell RNA-sequencing has emerged as a powerful technique for characterizing
cellular heterogeneity, but it is currently impractical on large sample cohorts and cannot be …

The clinical course of autoimmune and infectious disease varies greatly, even between
individuals with the same condition. An understanding of the molecular basis for this …

Type I interferons have been suspected for decades to have a crucial role in the
pathogenesis of systemic lupus erythematosus (SLE). Evidence has now overturned several …

Detailed population-level description of the human immune system has recently become
achievable. We used a'systems-level'approach to establish a resource of cellular immune …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

The effective and efficient management of cancer patients relies upon early diagnosis and/or
the monitoring of treatment, something that is often difficult to achieve using standard tissue …

Common human diseases result from the interplay of many genes and environmental
factors. Therefore, a more integrative biology approach is needed to unravel the complexity …

High-throughput experimental technologies are generating increasingly massive and
complex genomic data sets. The sheer enormity and heterogeneity of these data threaten to …