The oral administration of therapeutic peptides and proteins is favoured from a patient and
commercial point of view. In order to reach the systemic circulation after oral administration …

Throughout history, oral administration has been regarded as the most convenient mode of
drug delivery, as it requires minimal expertise and invasiveness. Although oral delivery …

Barberry (Berberis vulgaris L.) has different medicinal applications in folk medicine of Iran.
Berberine, an alkaloid constituent of this plant, is present in the roots, rhizomes, stem, and …

The formulation and delivery of biopharmaceutical drugs, such as monoclonal antibodies
and recombinant proteins, poses substantial challenges owing to their large size and …

In its 33 years, ADDR has published regularly on the po5tential of oral delivery of biologics
especially peptides and proteins. In the intervening period, analysis of the preclinical and …

Intestinal permeation enhancers (PEs) are one of the most widely tested strategies to
improve oral delivery of therapeutic peptides. This article assesses the intestinal permeation …

Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …

The natural product berberine (BBR) has become a potential drug in the treatment of
diabetes, hyperlipidemia, and cancer. However, the oral delivery of BBR is challenged by its …

Since the first attempt to administer insulin orally in humans more than 90 years ago, the oral
delivery of macromolecular drugs (> 1000 g/mol) has been rather disappointing. Although …

Background: Inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9)-low density
lipoprotein receptor interaction with injectable monoclonal antibodies or small interfering …