Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

The human brain depends on its blood supply for a continuous supply of oxygen and
glucose. Irreversible brain damage occurs if blood flow is reduced below about 10 ml/100 g …

Recent studies suggest that excitatory amino acids (EAAs) have a wide variety of
physiological and pathophysiological roles during central nervous system (CNS) …

Knowledge of the nature, prognosis, and ways to treat brain lesions in neonatal infants has
increased remarkably. Neonatal hypoxic-ischaemic encephalopathy (HIE) in term infants …

Hypoxic ischemia is a common cause of damage to the fetal and neonatal brain. Although
systemic and cerebrovascular physiologic factors play an important role in the initial phases …

Extracellular glutamate concentrations are regulated by glial and neuronal transporter
proteins. Four glutamate transporter subtypes have been identified in rat brain; GLAST and …

To gain insights into the pathogenesis and management of perinatal hypoxic‐ischemic brain
damage, the authors have used an immature rat model which they developed many years …

The same receptors for excitatory amino acids (EAA) that mediate direct neuronal
depolarization can also be responsible for neuronal injury. Prolonged stimulation of EAA …

Excitatory amino acids (EAA) such as glutamate and aspartate are major transmitters of the
cerebral cortex and hippocampus and EAA mechanisms appear to play a role in learning …

The oxygen supply to part of the brain can be cutoff by a loss of blood flow (ischaemia), for
example owing to cardiac arrest or a clot occluding a blood vessel, or by insufficient oxygen …