Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …

Aliment Pharmacol Ther 2011; 34: 146–165 Summary Background Factors other than acid
may play a role in gastro‐oesophageal reflux disease (GERD) and its complications. Aim To …

Elective transjugular intrahepatic portosystemic shunt (TIPS) placement can worsen
cognitive dysfunction in hepatic encephalopathy (HE) patients due to toxins, including …

The solute carrier (SLC) family 10 (SLC10) comprises influx transporters of bile acids,
steroidal hormones, various drugs, and several other substrates. Because the seminal …

Gastroesophageal reflux is associated with adenocarcinoma in Barrett's esophagus, but the
incidence of this tumor is rising, despite widespread use of acid-suppressing medications …

Bladder cancer (BC) is one of the most frequent cancer in the world, and its incidence is
rising worldwide, especially in developed countries. Urine metabolomics is a powerful …

A precancerous lesion of gastric cancer (GC), intestinal metaplasia (IM) is a pathological
transformation of non-intestinal epithelium into an intestinal-like mucosa. It greatly raises the …

Hydrophobic bile acids like deoxycholic acid (DCA), which cause oxidative DNA damage
and activate NF-κB in Barrett's metaplasia, might contribute to carcinogenesis in Barrett's …

Objective Barrett's oesophagus is a premalignant disease associated with oesophageal
adenocarcinoma. The major goal of this study was to determine the mechanism responsible …

Beclin-1 has a central role in the regulation of autophagy. Barrett's esophagus (BE) is
associated with a significantly increased risk for the development of esophageal …