Thoracic aortic aneurysm: clinically pertinent controversies and uncertainties

JA Elefteriades, EA Farkas - Journal of the American College of Cardiology, 2010 - jacc.org
This paper addresses clinical controversies and uncertainties regarding thoracic aortic
aneurysm and its treatment. 1) Estimating true aortic size is confounded by obliquity …

Molecular mechanisms of thoracic aortic dissection

D Wu, YH Shen, L Russell, JS Coselli… - Journal of Surgical …, 2013 - Elsevier
Thoracic aortic dissection (TAD) is a highly lethal vascular disease. In many patients with
TAD, the aorta progressively dilates and ultimately ruptures. Dissection formation …

A framework for geometric analysis of vascular structures: application to cerebral aneurysms

M Piccinelli, A Veneziani, DA Steinman… - IEEE transactions on …, 2009 - ieeexplore.ieee.org
There is well-documented evidence that vascular geometry has a major impact in blood flow
dynamics and consequently in the development of vascular diseases, like atherosclerosis …

[HTML][HTML] Evaluation of 3D blood flow patterns and wall shear stress in the normal and dilated thoracic aorta using flow-sensitive 4D CMR

J Bürk, P Blanke, Z Stankovic, A Barker… - Journal of …, 2012 - Elsevier
Background The purpose of this study was to investigate 3D flow patterns and vessel wall
parameters in patients with dilated ascending aorta, age-matched subjects, and healthy …

Predictive imaging for thoracic aortic dissection and rupture: moving beyond diameters

BP Adriaans, JE Wildberger, JJM Westenberg… - European …, 2019 - Springer
Acute aortic syndromes comprise a group of potentially fatal conditions that result from
weakening of the aortic vessel wall. Pre-emptive surgical intervention is currently reserved …

[HTML][HTML] Mechanisms of aortic dissection: from pathological changes to experimental and in silico models

M Rolf-Pissarczyk, R Schussnig, TP Fries… - Progress in Materials …, 2024 - Elsevier
Aortic dissection continues to be responsible for significant morbidity and mortality, although
recent advances in medical data assimilation and in experimental and in silico models have …

Oxidative stress modulates vascular smooth muscle cell phenotype via CTGF in thoracic aortic aneurysm

E Branchetti, P Poggio, R Sainger… - Cardiovascular …, 2013 - academic.oup.com
Aims Dissection and rupture of the ascending aorta are life-threatening conditions resulting
in 80% mortality. Ascending aortic replacement in patients presenting with thoracic aortic …

Pathogenesis of acute aortic dissection: a finite element stress analysis

DP Nathan, C Xu, JH Gorman III, RM Fairman… - The Annals of thoracic …, 2011 - Elsevier
BACKGROUND: Type A and type B aortic dissections typically result from intimal tears
above the sinotubular junction and distal to the left subclavian artery (LSA) ostium …

Natural history of thoracic aortic aneurysms: size matters, plus moving beyond size

KH Chau, JA Elefteriades - Progress in cardiovascular diseases, 2013 - Elsevier
Thoracic aortic aneurysms (TAAs) are a prevalent and deadly disease that, without
diagnosis and treatment, eventuates in life-threatening aortic dissection or rupture. While …

[HTML][HTML] Regional biomechanical characterization of human ascending aortic aneurysms: Microstructure and biaxial mechanical response

F Cosentino, S Sherifova, G Sommer, G Raffa, M Pilato… - Acta Biomaterialia, 2023 - Elsevier
The ascending thoracic aortic aneurysm (ATAA) is a permanent dilatation of the vessel with
a high risk of adverse events, and shows heterogeneous properties. To investigate regional …