Retinal ganglion cells (RGCs) are the brain's gateway for vision, and their degeneration
underlies several blinding diseases. RGCs interact with other neuronal cell types, microglia …

Importance As an accessible part of the central nervous system, the retina provides a unique
window to study pathophysiological mechanisms of brain disorders in humans. Imaging and …

There is a growing need to better characterise senescent cells in the CNS and retina. The
recently published SenMayo gene panel was developed to identify transcriptomic signatures …

The retina extracts chromatic information present in an animal's environment. How this
information is processed in the retina is not well understood. In the mouse, chromatic …

ABSTRACT Homeobox transcription factor Engrailed1 (En1) is expressed in the ectoderm
and mediates the establishment of retinotectal topography, but its role in eye‐specific …

Docosahexaenoic acid (DHA), a dietary omega-3 fatty acid, is a major building block of brain
cell membranes. Offspring rely on maternal DHA transfer to meet their neurodevelopmental …

Armadillo repeat‐containing X‐linked protein‐1 (Armcx1) is a poorly characterized
transmembrane protein that regulates mitochondrial transport in neurons. Its overexpression …

Single-cell transcriptomic analyses have emerged as very powerful tools to query the gene
expression changes at the single-cell level in physiological and pathological conditions. The …

This dissertation describes my efforts to explore the functions of the poorly-characterized
mitochondrial protein Armcx1. Armcx1 has previously been shown increase neurite …