BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …

There is a pressing need to capture and track subtle cognitive change at the preclinical
stage of Alzheimer's disease (AD) rapidly, cost‐effectively, and with high sensitivity …

The hippocampus is critical for learning and memory, relying in part on pattern separation
processes supported by the dentate gyrus (DG) to prevent interference from overlapping …

Meditation is an ancient practice that cultivates a calm yet focused mind; however, little is
known about how short, practical meditation practices affect cognitive functioning in …

The ability to discriminate among similar experiences is a crucial feature of episodic
memory. This ability has long been hypothesized to require the hippocampus, and …

Elevated hippocampal activation is observed in conditions that confer risk for Alzheimer's
disease, including amnestic mild cognitive impairment (aMCI). Studies in relevant animal …

Pattern separation, the ability to independently represent and store similar experiences, is a
crucial facet of episodic memory. Growing evidence suggests that the hippocampus …

Pattern separation, the process of transforming similar representations or memories into
highly dissimilar, nonoverlapping representations, is a key component of many functions …

There is widespread evidence that memory deteriorates with aging, however the exact
mechanisms that underlie these changes are not well understood. Given the growing size of …

Focusing primarily on functional magnetic resonance imaging (fMRI), this article reviews
evidence regarding the roles of subregions of the medial temporal lobes, prefrontal cortex …