Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target
Understanding HIV-1–host interactions can identify the cellular environment supporting HIV-
1 reactivation and mechanisms of clonal expansion. We developed HIV-1 SortSeq to isolate …
1 reactivation and mechanisms of clonal expansion. We developed HIV-1 SortSeq to isolate …
OncoMX: a knowledgebase for exploring cancer biomarkers in the context of related cancer and healthy data
HM Dingerdissen, F Bastian… - JCO clinical cancer …, 2020 - ascopubs.org
PURPOSE The purpose of OncoMX knowledgebase development was to integrate cancer
biomarker and relevant data types into a meta-portal, enabling the research of cancer …
biomarker and relevant data types into a meta-portal, enabling the research of cancer …
Tumor mutation burden, immune checkpoint crosstalk and radiosensitivity in single-cell RNA sequencing data of breast cancer
BS Jang, W Han, IA Kim - Radiotherapy and Oncology, 2020 - Elsevier
Introduction We analyzed transcriptional and mutational profile mainly focused on tumor
mutation burden (TMB), immune checkpoint crosstalk, and radiosensitivity using scRNA-seq …
mutation burden (TMB), immune checkpoint crosstalk, and radiosensitivity using scRNA-seq …
scruff: an R/Bioconductor package for preprocessing single-cell RNA-sequencing data
Background Single-cell RNA sequencing (scRNA-seq) enables the high-throughput
quantification of transcriptional profiles in single cells. In contrast to bulk RNA-seq, additional …
quantification of transcriptional profiles in single cells. In contrast to bulk RNA-seq, additional …
SCHNAPPs-single cell sHiNy APPlication (s)
Single-cell RNA-sequencing (scRNAseq) experiments are becoming a standard tool for
bench-scientists to explore the cellular diversity present in all tissues. Data produced by …
bench-scientists to explore the cellular diversity present in all tissues. Data produced by …
Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airways
SARS-CoV-2 infection and disease severity are influenced by viral entry (VE) gene
expression patterns in the airway epithelium. The similarities and differences of VE gene …
expression patterns in the airway epithelium. The similarities and differences of VE gene …
CD29 marks superior cytotoxic human T cells
BP Nicolet, A Guislain, FPJ van Alphen… - bioRxiv, 2019 - biorxiv.org
Cytotoxic CD8+ T cells can effectively kill target cells by producing cytokines, chemokines
and granzymes. Expression of these effector molecules is however highly divergent, and …
and granzymes. Expression of these effector molecules is however highly divergent, and …
Multi-Modal Profiling of Human Fetal Liver-Derived Hematopoietic Stem Cells Reveals the Molecular Signature of Engraftment Potential
K Vanuytsel, C Villacorta-Martin, J Lindstrom-Vautrin… - bioRxiv, 2020 - biorxiv.org
The human hematopoietic stem cell (HSC) harbors remarkable regenerative potential that
can be harnessed therapeutically. During early development, HSCs in the fetal liver (FL) …
can be harnessed therapeutically. During early development, HSCs in the fetal liver (FL) …
[图书][B] Comprehensive Analysis of Glycosyltransferases in Cancer Identified from a Multifaceted Genomics Approach
HM Dingerdissen - 2021 - search.proquest.com
Despite accumulating evidence supporting a role for glycosylation in cancer progression
and prognosis, the complexity of the human glycome and study thereof poses many …
and prognosis, the complexity of the human glycome and study thereof poses many …
Lung Adenocarcinoma Intratumoral Expression Heterogeneity Profiling Using Single-Cell RNA-seq Data
EJ Holmes - 2020 - search.proquest.com
The heterogeneity of tumors frequently challenge cancer treatment and diagnosis efficacy.
Features of genes in tumors such as expression profiles can vary between tumors and …
Features of genes in tumors such as expression profiles can vary between tumors and …