[HTML][HTML] A focused review on CB2 receptor-selective pharmacological properties and therapeutic potential of β-caryophyllene, a dietary cannabinoid

HM Hashiesh, C Sharma, SN Goyal, B Sadek… - Biomedicine & …, 2021 - Elsevier
The endocannabinoid system (ECS), a conserved physiological system emerged as a novel
pharmacological target for its significant role and potential therapeutic benefits ranging from …

Therapeutic potential of β-caryophyllene: a dietary cannabinoid in diabetes and associated complications

HM Hashiesh, MFN Meeran, C Sharma, B Sadek… - Nutrients, 2020 - mdpi.com
Diabetes mellitus (DM), a metabolic disorder is one of the most prevalent chronic diseases
worldwide across developed as well as developing nations. Hyperglycemia is the core …

Cytosine-5 RNA methylation links protein synthesis to cell metabolism

NA Gkatza, C Castro, RF Harvey, M Heiß… - PLoS …, 2019 - journals.plos.org
Posttranscriptional modifications in transfer RNA (tRNA) are often critical for normal
development because they adapt protein synthesis rates to a dynamically changing …

Lipid metabolism and plasma metabolomics of juvenile largemouth bass Micropterus salmoides were affected by dietary oxidized fish oil

S Xie, P Yin, L Tian, Y Liu, J Niu - Aquaculture, 2020 - Elsevier
During the storage, fish oil is susceptible to peroxidation to form toxic lipid derivatives,
dietary intake of oxidized fish oil would induce oxidative stress and inflammation in animals …

Current and future treatments in the fight against non-alcoholic fatty liver disease

B Smeuninx, E Boslem, MA Febbraio - Cancers, 2020 - mdpi.com
Obesity is recognised as a risk factor for many types of cancers, in particular hepatocellular
carcinoma (HCC). A critical factor in the development of HCC from non-alcoholic fatty liver …

Synthetic and natural Peroxisome Proliferator-Activated Receptor (PPAR) agonists as candidates for the therapy of the metabolic syndrome

CK Tan, Y Zhuang, W Wahli - Expert opinion on therapeutic targets, 2017 - Taylor & Francis
Introduction: Peroxisome proliferator-activated receptors (PPARs) are the molecular targets
of hypolipidemic and insulin-sensitizing drugs and implicated in a multitude of processes …

Integration of metabolomics, lipidomics and clinical data using a machine learning method

A Acharjee, Z Ament, JA West, E Stanley, JL Griffin - BMC bioinformatics, 2016 - Springer
Background The recent pandemic of obesity and the metabolic syndrome (MetS) has led to
the realisation that new drug targets are needed to either reduce obesity or the subsequent …

[HTML][HTML] Dehydroabietic acid alleviates high fat diet-induced insulin resistance and hepatic steatosis through dual activation of PPAR-γ and PPAR-α

Z Xie, G Gao, H Wang, E Li, Y Yuan, J Xu… - Biomedicine & …, 2020 - Elsevier
Dual-PPAR-α/γ agonist has the dual potentials to improve insulin resistance (IR) and hepatic
steatosis associated with obesity. This study aimed to investigate whether dehydroabietic …

The effects of 6-month vitamin D supplementation during the non-surgical treatment of periodontitis in vitamin-D-deficient patients: a randomized double-blind placebo …

M Perić, D Maiter, E Cavalier, JF Lasserre, S Toma - Nutrients, 2020 - mdpi.com
Background: This study assessed the effects of weekly vitamin D (VD) supplementation on
clinical and biological parameters after scaling and root planning (SRP) in the treatment of …

[HTML][HTML] Silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells

G Vecchione, E Grasselli, A Voci, F Baldini… - World journal of …, 2016 - ncbi.nlm.nih.gov
AIM: To investigate in vitro the therapeutic effect and mechanisms of silybin in a cellular
model of hepatic steatosis. METHODS: Rat hepatoma FaO cells were loaded with lipids by …