Liquid–Liquid Phase Separation and protective protein aggregates in bacteria

D Kuczyńska-Wiśnik, K Stojowska-Swędrzyńska… - Molecules, 2023 - mdpi.com
Liquid–liquid phase separation (LLPS) and the formation of membraneless organelles
(MLOs) contribute to the spatiotemporal organization of various physiological processes in …

The rise and future of CRISPR-based approaches for high-throughput genomics

S Vercauteren, S Fiesack, L Maroc… - FEMS microbiology …, 2024 - academic.oup.com
Clustered regularly interspaced short palindromic repeats (CRISPR) has revolutionized the
field of genome editing. To circumvent the permanent modifications made by traditional …

Intoxication of antibiotic persisters by host RNS inactivates their efflux machinery during infection

S Ronneau, C Michaux, RT Giorgio, S Helaine - Plos Pathogens, 2024 - journals.plos.org
The host environment is of critical importance for antibiotic efficacy. By impacting bacterial
machineries, stresses encountered by pathogens during infection promote the formation of …

Influence of Nε-Lysine Acetylation on the Formation of Protein Aggregates and Antibiotic Persistence in E. coli

K Stojowska-Swędrzyńska, D Kuczyńska-Wiśnik… - Molecules, 2024 - mdpi.com
Numerous studies indicate that reversible Nε-lysine acetylation in bacteria may play a key
role in the regulation of metabolic processes, transcription and translation, biofilm formation …

[HTML][HTML] Response mechanisms of resistance in L-form bacteria to different target antibiotics: Implications from oxidative stress to metabolism

Y Zheng, Y Cai, T Sun, G Li, T An - Environment International, 2024 - Elsevier
Due to the specific action on bacterial cell wall, β-lactam antibiotics have gained widespread
usage as they exhibit a high degree of specificity in targeting bacteria, but causing minimal …

[HTML][HTML] Biofilm Formation, Antibiotic Resistance, and Infection (BARI): The Triangle of Death

V Giordano, PV Giannoudis - Journal of Clinical Medicine, 2024 - pmc.ncbi.nlm.nih.gov
Fracture-related infection (FRI) is a devastating event, directly affecting fracture healing,
impairing patient function, prolonging treatment, and increasing healthcare costs. Time plays …

A single upstream mutation of whiB7 underlies amikacin and clarithromycin resistance in Mycobacterium abscessus

N De Boeck, C Villellas, E Crespo-Yuste… - Journal of Applied …, 2024 - academic.oup.com
Aims We aimed to investigate the molecular mechanisms underlying the survival of
Mycobacterium abscessus when faced with antibiotic combination therapy. By conducting …

Proton motive force and antibiotic tolerance in bacteria

Y Wan, J Zheng, EWC Chan, S Chen - Microbial biotechnology, 2024 - Wiley Online Library
Bacterial antibiotic tolerance is a decades‐old phenomenon in which a bacterial sub‐
population, commonly known as persisters, does not respond to antibiotics and remains …

The causal relationship between gut microbiota and nine infectious diseases: a two-sample Mendelian randomization analysis

S Wang, F Yin, W Sun, R Li, Z Guo, Y Wang… - Frontiers in …, 2024 - frontiersin.org
Background Evidence from observational studies and clinical trials has associated gut
microbiota with infectious diseases. However, the causal relationship between gut …

Effects of Alhagi camelorum Fisch polysaccharide from different regions on growth performance and gastrointestinal microbiota of sheep lambs

Z Manafu, Z Zhang, X Malajiang, S Abula… - Frontiers in …, 2024 - frontiersin.org
Polysaccharides derived from Alhagi camelorum Fisch possess diverse activities, making
them a potential prebiotic candidates for enhancing lamb health. This study investigated the …