Substituted and annulated pyrroles containing chiral centers are potentially accessible by
means of an organocatalytic enantioselective Friedel‐Crafts alkylation (FCA) reaction. They …

The wide occurrence of pyrroles in natural products and pharmaceuticals calls for novel
synthetic methodologies for the efficient synthesis of enantiopure pyrroles. Owing to their …

Chiral chloro-indeno pybox has served as a new ligand for the Yb (OTf) 3-catalyzed
asymmetric Friedel–Crafts alkylation reaction of indoles with nitroalkenes. The tunable …

Abstract The Friedel-Crafts alkylation (F-CA) reaction is a distinct sort of Csingle bondC
bond formations. It is often used for the formation of Csingle bondC bonds to aromatic rings …

A highly enantioselective Friedel–Crafts (F–C) alkylation of pyrrole with a wide range of
simple nonchelating chalcone derivatives catalyzed by a chiral (Zn2EtL) n (L=(S, S)-1) …

Abstract The Friedel‐Crafts alkylation (F‐CA) reaction is a special kind of carbon− carbon
bond formations, which is frequently being used for the formation of such bond in some …

A series of chiral bifunctional quinine and 2-aminoDMAP based squaramide
organocatalysts are evaluated in Friedel-Crafts alkylation of indoles with nitroolefins. These …

Functionalization of pyrroles introducing a 2-nitroalkyl moiety allows the formation of nitro-
containing compounds to be used as pivotal intermediates for the synthesis of bioactive …

Synthetic strategies towards pyrroles within chiral frameworks are summarised, focussing on
reports published 2010–2023. The synthesis of pyrroles featuring substituents bearing chiral …

A substitutionally and configurationally inert octahedral chiral-at-metal iridium complex is
reported to be an efficient catalyst for the enantioselective Friedel–Crafts alkylation of 2, 5 …