Oxidative stress and 4‐hydroxy‐2‐nonenal (4‐HNE): Implications in the pathogenesis and treatment of aging‐related diseases

Y Li, T Zhao, J Li, M Xia, Y Li, X Wang… - Journal of …, 2022 - Wiley Online Library
Oxidative stress plays an important role in the development of aging‐related diseases by
accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell membrane …

Oxidative stress and energy metabolism in the brain: Midlife as a turning point

VI Lushchak, M Duszenko, DV Gospodaryov… - Antioxidants, 2021 - mdpi.com
Neural tissue is one of the main oxygen consumers in the mammalian body, and a
plentitude of metabolic as well as signaling processes within the brain is accompanied by …

Translational block in stroke: a constructive and “out-of-the-box” reappraisal

A Lourbopoulos, I Mourouzis, C Xinaris… - Frontiers in …, 2021 - frontiersin.org
Why can we still not translate preclinical research to clinical treatments for acute strokes?
Despite> 1000 successful preclinical studies, drugs, and concepts for acute stroke, only two …

Intermittent fasting, fatty acid metabolism reprogramming, and neuroimmuno microenvironment: mechanisms and application prospects

A Zhang, J Wang, Y Zhao, Y He, N Sun - Frontiers in Nutrition, 2024 - frontiersin.org
Intermittent fasting (IF) has demonstrated extensive health benefits through the regulation of
fatty acid metabolism and modulation of the neuroimmune microenvironment, primarily via …

Diabetic wound healing potential of silk sericin protein based hydrogels enriched with plant extracts

S Zahoor, HM Tahir, S Ali, A Ali, A Muzamil… - International Journal of …, 2023 - Elsevier
The complications associated with diabetic wounds make their healing process prolonged.
Hydrogels could be ideal wound dressings therefore present research was conducted to …

Metabolic Syndrome: Lessons from Rodent and Drosophila Models

MV Vatashchuk, MM Bayliak, VV Hurza… - BioMed Research …, 2022 - Wiley Online Library
Overweight and obesity are health conditions tightly related to a number of metabolic
complications collectively called “metabolic syndrome”(MetS). Clinical diagnosis of MetS …

Chronic intermittent fasting impairs β cell maturation and function in adolescent mice

L Matta, P Weber, S Erener, A Walth-Hummel, D Hass… - Cell Reports, 2025 - cell.com
Intermittent fasting (IF) is a nutritional lifestyle intervention with broad metabolic benefits, but
whether the impact of IF depends on the individual's age is unclear. Here, we investigated …

Benefits, mechanisms, and risks of intermittent fasting in metabolic syndrome and type 2 diabetes

L Joaquim, A Faria, H Loureiro, P Matafome - Journal of physiology and …, 2022 - Springer
One of the emergent nutritional strategies for improving multiple features of cardiometabolic
diseases is the practice of intermittent fasting (IF), which consists of alternating periods of …

Preservation of mitochondrial membrane potential is necessary for lifespan extension from dietary restriction

BJ Berry, E Mjelde, F Carreno, K Gilham, EJ Hanson… - GeroScience, 2023 - Springer
Dietary restriction (DR) increases lifespan in many organisms, but its underlying
mechanisms are not fully understood. Mitochondria play a central role in metabolic …

Changing functional signatures of microglia along the axis of brain aging

B Brawek, M Skok, O Garaschuk - International journal of molecular …, 2021 - mdpi.com
Microglia, the innate immune cells of the brain, are commonly perceived as resident
macrophages of the central nervous system (CNS). This definition, however, requires further …