Polyhydroxyalkanoates bioproduction from bench to industry: thirty years of development towards sustainability
The pursuit of carbon neutrality goals has sparked considerable interest in expanding
bioplastics production from microbial cell factories. One prominent class of bioplastics …
bioplastics production from microbial cell factories. One prominent class of bioplastics …
Biosensor-enabled pathway optimization in metabolic engineering
Microbes can convert inexpensive renewable substrates to valuable metabolites by their
natural metabolic pathways. To maximize the productivity, the pathways yet require further …
natural metabolic pathways. To maximize the productivity, the pathways yet require further …
Multidimensional characterization of inducible promoters and a highly light-sensitive LOV-transcription factor
The ability to independently control the expression of different genes is important for
quantitative biology. Using budding yeast, we characterize GAL1pr, GALL, MET3pr, CUP1pr …
quantitative biology. Using budding yeast, we characterize GAL1pr, GALL, MET3pr, CUP1pr …
Biosensor for branched-chain amino acid metabolism in yeast and applications in isobutanol and isopentanol production
Branched-chain amino acid (BCAA) metabolism fulfills numerous physiological roles and
can be harnessed to produce valuable chemicals. However, the lack of eukaryotic …
can be harnessed to produce valuable chemicals. However, the lack of eukaryotic …
A Toolkit for Precise, Multigene Control in Saccharomyces cerevisiae
A Sanford, S Kiriakov, AS Khalil - ACS Synthetic Biology, 2022 - ACS Publications
Systems that allow researchers to precisely control the expression of genes are fundamental
to biological research, biotechnology, and synthetic biology. However, few inducible gene …
to biological research, biotechnology, and synthetic biology. However, few inducible gene …
Optogenetic amplification circuits for light-induced metabolic control
EM Zhao, MA Lalwani, JM Chen, P Orillac… - ACS synthetic …, 2021 - ACS Publications
Dynamic control of microbial metabolism is an effective strategy to improve chemical
production in fermentations. While dynamic control is most often implemented using …
production in fermentations. While dynamic control is most often implemented using …
Optogenetic control of microbial consortia populations for chemical production
MA Lalwani, H Kawabe, RL Mays… - ACS Synthetic …, 2021 - ACS Publications
Microbial co-culture fermentations can improve chemical production from complex
biosynthetic pathways over monocultures by distributing enzymes across multiple strains …
biosynthetic pathways over monocultures by distributing enzymes across multiple strains …
Optogenetics illuminates applications in microbial engineering
SM Hoffman, AY Tang, JL Avalos - Annual review of chemical …, 2022 - annualreviews.org
Optogenetics has been used in a variety of microbial engineering applications, such as
chemical and protein production, studies of cell physiology, and engineered microbe–host …
chemical and protein production, studies of cell physiology, and engineered microbe–host …
Engineering conditional protein-protein interactions for dynamic cellular control
Conditional protein-protein interactions enable dynamic regulation of cellular activity and
are an attractive approach to probe native protein interactions, improve metabolic …
are an attractive approach to probe native protein interactions, improve metabolic …
Optogenetic tools for microbial synthetic biology
Chemical induction is one of the most common modalities used to manipulate gene
expression in living systems. However, chemical induction can be toxic or expensive that …
expression in living systems. However, chemical induction can be toxic or expensive that …