Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Sepsis can be caused by a broad range of pathogens; however, bacterial …

Toll-like receptors (TLRs) are fundamental sensor molecules of the host innate immune
system, which detect conserved molecular signatures of a wide range of microbial …

Abstract Toll-like receptor 8 (TLR8) recognizes viral or bacterial single-stranded RNA
(ssRNA) and activates innate immune systems. TLR8 is activated by uridine-and guanosine …

Toll-like receptors (TLRs) are pattern recognition receptors that play a central role in the
development and function of the immune system. TLR signaling promotes the earliest …

Toll-like receptor 7 (TLR7) and TLR8 recognize single-stranded RNA and initiate innate
immune responses. Several synthetic agonists of TLR7-TLR8 display novel therapeutic …

In human myocarditis and its sequela dilated cardiomyopathy (DCM), the mechanisms and
immune phenotype governing disease and subsequent heart failure are not known. Here …

Despite advances in treatment of patients who suffer from ischemic heart disease, morbidity
related to myocardial infarction is increasing in Western societies. Acute and chronic …

Abstract The coronavirus disease‐2019 (COVID‐19) pandemic caused by severe acute
respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has already resulted in a huge setback …

The live attenuated yellow fever vaccine 17D (YF-17D) is one of the most effective vaccines
available, with a 65-yr history of use in> 400 million people globally. Despite this efficacy …

Cardiovascular disease is a leading cause of death worldwide and is associated with
systemic inflammation. In depth study of the cell-specific signaling mechanisms mediating …