Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions

S Vatansever, A Schlessinger, D Wacker… - Medicinal research …, 2021 - Wiley Online Library
Neurological disorders significantly outnumber diseases in other therapeutic areas.
However, developing drugs for central nervous system (CNS) disorders remains the most …

[HTML][HTML] Incorporating machine learning into established bioinformatics frameworks

N Auslander, AB Gussow, EV Koonin - International journal of molecular …, 2021 - mdpi.com
The exponential growth of biomedical data in recent years has urged the application of
numerous machine learning techniques to address emerging problems in biology and …

A comprehensive analysis of artificial intelligence techniques for the prediction and prognosis of genetic disorders using various gene disorders

N Chaplot, D Pandey, Y Kumar, PS Sisodia - Archives of Computational …, 2023 - Springer
A medical analysis of diagnosing rare genetic diseases has rapidly become the most
expensive and time-consuming component for doctors. By combining predictive methods …

Semantic data mining in the information age: A systematic review

C Sirichanya, K Kraisak - International Journal of Intelligent …, 2021 - Wiley Online Library
Data mining is the discovery of meaningful information or unrevealed patterns in data.
Traditional data‐mining approaches, using statistical calculations, machine learning …

Time-series classification with SAFE: Simple and fast segmented word embedding-based neural time series classifier

N Tabassum, S Menon, A Jastrzębska - Information Processing & …, 2022 - Elsevier
Dictionary-based classifiers are an essential group of approaches in the field of time series
classification. Their distinctive characteristic is that they transform time series into segments …

Negative selection on human genes underlying inborn errors depends on disease outcome and both the mode and mechanism of inheritance

F Rapaport, B Boisson, A Gregor… - Proceedings of the …, 2021 - National Acad Sciences
Genetic variants underlying life-threatening diseases, being unlikely to be transmitted to the
next generation, are gradually and selectively eliminated from the population through …

IoMT‐Based Mitochondrial and Multifactorial Genetic Inheritance Disorder Prediction Using Machine Learning

A Rahman, MU Nasir, M Gollapalli… - Computational …, 2022 - Wiley Online Library
A genetic disorder is a serious disease that affects a large number of individuals around the
world. There are various types of genetic illnesses, however, we focus on mitochondrial and …

What are the challenges with multi-targeted drug design for complex diseases?

A Zięba, P Stępnicki, D Matosiuk… - Expert Opinion on Drug …, 2022 - Taylor & Francis
Introduction Current findings on multifactorial diseases with a complex pathomechanism
confirm that multi-target drugs are more efficient ways in treating them as opposed to single …

Biomedical knowledge graph embeddings for personalized medicine: Predicting disease‐gene associations

J Vilela, M Asif, AR Marques, JX Santos… - Expert …, 2023 - Wiley Online Library
Personalized medicine is a concept that has been subject of increasing interest in medical
research and practice in the last few years. However, significant challenges stand in the way …

[HTML][HTML] Predicting Parkinson disease related genes based on PyFeat and gradient boosted decision tree

M Helmy, E Eldaydamony, N Mekky, M Elmogy… - Scientific Reports, 2022 - nature.com
Identifying genes related to Parkinson's disease (PD) is an active research topic in
biomedical analysis, which plays a critical role in diagnosis and treatment. Recently, many …