Oestradiol as a neuromodulator of learning and memory

LR Taxier, KS Gross, KM Frick - Nature Reviews Neuroscience, 2020 - nature.com
Although hormones such as glucocorticoids have been broadly accepted in recent decades
as general neuromodulators of memory processes, sex steroid hormones such as the potent …

The neuroprotective actions of oestradiol and oestrogen receptors

MA Arevalo, I Azcoitia, LM Garcia-Segura - Nature Reviews …, 2015 - nature.com
Hormones regulate homeostasis by communicating through the bloodstream to the body's
organs, including the brain. As homeostatic regulators of brain function, some hormones …

[HTML][HTML] Role of estrogen and other sex hormones in brain aging. Neuroprotection and DNA repair

S Zárate, T Stevnsner, R Gredilla - Frontiers in aging neuroscience, 2017 - frontiersin.org
Aging is an inevitable biological process characterized by a progressive decline in
physiological function and increased susceptibility to disease. The detrimental effects of …

Insulin-like growth factor-1 and neuroinflammation

JL Labandeira-Garcia, MA Costa-Besada… - Frontiers in aging …, 2017 - frontiersin.org
Insulin-like growth factor-1 (IGF-1) effects on aging and neurodegeneration is still
controversial. However, it is widely admitted that IGF-1 is involved in the neuroinflammatory …

Targeting nuclear receptors in neurodegeneration and neuroinflammation

S Willems, D Zaienne, D Merk - Journal of medicinal chemistry, 2021 - ACS Publications
Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …

Growth hormone and cognitive function

F Nyberg, M Hallberg - Nature Reviews Endocrinology, 2013 - nature.com
Emerging data indicate that growth hormone (GH) therapy could have a role in improving
cognitive function. GH replacement therapy in experimental animals and human patients …

Ginsenoside Rg5 improves cognitive dysfunction and beta-amyloid deposition in STZ-induced memory impaired rats via attenuating neuroinflammatory responses

S Chu, J Gu, L Feng, J Liu, M Zhang, X Jia, M Liu… - International …, 2014 - Elsevier
Neuroinflammatory responses play a crucial role in the pathogenesis of Alzheimer's disease
(AD). Ginsenoside Rg5 (Rg5), an abundant natural compound in Panax ginseng, has been …

Enriched early life experiences reduce adult anxiety-like behavior in rats: a role for insulin-like growth factor 1

S Baldini, L Restani, L Baroncelli, M Coltelli… - Journal of …, 2013 - Soc Neuroscience
Early life experiences can affect brain development, contributing to shape interindividual
differences in stress vulnerability and anxiety-like behavior. In rodents, high levels of …

Distribution of growth hormone-responsive cells in the mouse brain

IC Furigo, M Metzger, PDS Teixeira… - Brain Structure and …, 2017 - Springer
Growth hormone (GH) exerts important biological effects primarily related to growth and
metabolism. However, the role of GH signaling in the brain is still elusive. To better …

The role of estrogen in anxiety-like behavior and memory of middle-aged female rats

E Renczés, V Borbélyová, M Steinhardt… - Frontiers in …, 2020 - frontiersin.org
Aging in women is associated with low estrogen, but also with cognitive decline and
affective disorders. Whether low estrogen is causally responsible for these behavioral …