Aberrant patterns of brain functional connectivity in the default mode network (DMN) have
been observed across different classes of substance use disorder (SUD) and are associated …

A substantial number of people who have problems with alcohol also experience strong
anxiety and mood problems. This article provides an overview of the evolving perspectives …

Epidemiological data demonstrate that while women report lower rates of drug use than
men, the number of current drug users and abusers who are women continues to increase …

Converging lines of evidence suggest that the pathophysiology of pain is mediated to a
substantial degree via allostatic neuroadaptations in reward-and stress-related brain …

Negative urgency is a unique dimension of impulsivity that involves acting rashly when in
extreme distress and impairments in inhibitory control. It has been hypothesized to derive …

Abstract The endogenous neurosteroid (3α, 5α) 3-hydroxypregnan-20-one (3α, 5α-THP,
allopregnanolone) has protective activity in animal models of alcoholism, depression …

Substance use disorder (SUD) is a chronic condition characterized by pathological drug-
taking and seeking behaviors. remarkably different between males and females, suggesting …

Sleep health is an important factor across several physical and mental health disorders, and
a growing scientific consensus has identified sleep as a critical component of opioid use …

Background Precision medicine aims to identify those patients who will benefit the most from
specific treatments. Recent work found large effects of naltrexone among “reward drinkers,” …

There is a pressing need to better understand the factors contributing to prescription opioid
misuse among patients with chronic pain. Cross-sectional studies have been conducted in …