Annexin A3, a calcium-dependent phospholipid-binding protein: Implication in cancer

L Yang, P Lu, X Yang, K Li, S Qu - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Annexin A3 (ANXA3), also known as lipocortin III and placental anticoagulant protein III, has
been reported to be dysregulated in tumor tissues and cancer cell lines, and harbors …

Grade-dependent metabolic reprogramming in kidney cancer revealed by combined proteomics and metabolomics analysis

HI Wettersten, AA Hakimi, D Morin, C Bianchi… - Cancer research, 2015 - AACR
Kidney cancer [or renal cell carcinoma (RCC)] is known as “the internist's tumor” because it
has protean systemic manifestations, suggesting that it utilizes complex, nonphysiologic …

The role of annexin A3 playing in cancers

N Wu, S Liu, C Guo, Z Hou, MZ Sun - Clinical and Translational Oncology, 2013 - Springer
Annexin family proteins are a well-known multigene family of Ca 2+-regulated phospholipid-
and membrane-binding proteins. As one of the annexin family genes/proteins, accumulated …

The cross‐talk between Abl2 tyrosine kinase and TGFβ1 signalling modulates the invasion of clear cell renal cell carcinoma cells

S De Marco, B Torsello, E Minutiello, I Morabito… - FEBS …, 2023 - Wiley Online Library
Clear cell Renal Cell Carcinoma (ccRCC) is the most common and metastatic urological
cancer. Molecular players of ccRCC progression and metastasis are not completely known …

[HTML][HTML] 36-kDa annexin A3 isoform negatively modulates lipid storage in clear cell renal cell carcinoma cells

S Bombelli, B Torsello, S De Marco, G Lucarelli… - The American journal of …, 2020 - Elsevier
The adipocyte-like morphology of clear cell renal cell carcinoma (ccRCC) cells results from a
grade-dependent neutral lipid accumulation; however, the molecular mechanism and role in …

[HTML][HTML] The glucose and lipid metabolism reprogramming is grade-dependent in clear cell renal cell carcinoma primary cultures and is targetable to modulate cell …

C Bianchi, C Meregalli, S Bombelli, V Di Stefano… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Clear cell renal cell carcinoma (ccRCC) has a poor prognosis despite novel biological
targeted therapies. Tumor aggressiveness and poor survival may correlate with tumor grade …

Secretion of annexin A3 from ovarian cancer cells and its association with platinum resistance in ovarian cancer patients

J Yin, X Yan, X Yao, Y Zhang, Y Shan… - Journal of cellular …, 2012 - Wiley Online Library
Early detection of resistance to platinum‐based therapy is critical for improving the treatment
of ovarian cancers. We have previously found that increased expression of annexin A3 is a …

Pathobiological functions and clinical implications of annexin dysregulation in human cancers

L Prieto-Fernández, ST Menéndez… - Frontiers in cell and …, 2022 - frontiersin.org
Annexins are an extensive superfamily of structurally related calcium-and phospholipid-
binding proteins, largely conserved and widely distributed among species. Twelve human …

Annexin A3 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma

QZ Pan, K Pan, DS Weng, JJ Zhao… - Molecular …, 2015 - Wiley Online Library
Annexin A3 (ANXA3) has been found to play important roles in cancer progression,
metastasis, and drug resistance; however, its role in hepatocellular carcinoma (HCC) …

[HTML][HTML] 33-kDa ANXA3 isoform contributes to hepatocarcinogenesis via modulating ERK, PI3K/Akt-HIF and intrinsic apoptosis pathways

C Guo, N Li, C Dong, L Wang, Z Li, Q Liu, Q Ma… - Journal of Advanced …, 2021 - Elsevier
Introduction As a member of annexin family proteins, annexin A3 (ANXA3) has 36-kDa and
33-kDa isoforms. ANXA3 plays crucial roles in the tumorigenesis, aggressiveness and drug …