The initial view of the renin-angiotensin system focused on the role of angiotensin II as a
hormone involved in blood pressure control, based on its role in renal salt and water …

Vascular inflammation is involved in the initiation and progression of atherosclerosis, and is
also present in hypertension-and diabetes-induced vascular complications. Angiotensin II …

838 medication have significant differences with regard to their ancillary pharmacological
properties and thereby also their profile at a molecular/cellular level. Furthermore, these …

Objectives: We evaluated whether renin-angiotensin system (RAS) blockade attenuates
cardiovascular events. Background: Because inflammation and enhanced thrombogenesis …

Objectives: We investigated the vascular effects of candesartan in hypertensive patients.
Background: The renin-angiotensin system may contribute to atherogenesis through the …

The cardiac extracellular matrix (ECM) provides the architectural scaffold to support efficient
contraction and relaxation of cardiomyocytes. The elegant design of the ECM facilitates …

Highly selective angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) are now
available. The AT1 receptor is a member of the G protein-coupled receptor (GPCR) …

Pharmacologically active metabolites can contribute significantly to the overall therapeutic
and adverse effects of drugs. Therefore, to fully understand the mechanism of action of …

The renin angiotensin system (RAS) is one of the most powerful regulators of blood pressure
and volume homeostasis in mammals. Its effector peptide angiotensin II (ANG II) is cleaved …

The concept of local renin–angiotensin systems has been introduced almost 20 years ago to
explain the beneficial blood pressure-independent effects of ACE inhibitors and AT1 …