The BAFF-receptor (BAFFR) is encoded by the TNFRSF13C gene and is one of the main pro-
survival receptors in B cells. Its function is impressively documented in humans by a …

Therapeutic targeting of immune checkpoints has garnered significant attention in the area
of cancer immunotherapy, in which efforts have focused in particular on cytotoxic T …

The International Collaboration in Asthma, Allergy and Immunology initiated an international
coalition among the American Academy of Allergy, Asthma & Immunology; the European …

Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by
autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I …

B cells develop from hematopoietic precursor cells in an ordered maturation and selection
process. Extensive studies with many different mouse mutants provided fundamental …

Background Common variable immunodeficiency (CVID) is an antibody deficiency with an
equal sex distribution and a high variability in clinical presentation. The main features …

Secondary lymphoid tissues share the important function of bringing together antigens and
rare antigen‐specific lymphocytes to foster induction of adaptive immune responses. Peyer's …

T cell help to B cells is a fundamental aspect of adaptive immunity and the generation of
immunological memory. Follicular helper CD4 T (TFH) cells are the specialized providers of …

The demographics, immunologic parameters, medical complications, and mortality statistics
from 473 subjects with common variable immune deficiency followed over 4 decades in New …

Non-infectious complications in common variable immunodeficiency (CVID) have emerged
as a major clinical challenge. Detailed clinical spectrum, organ-specific pathologies and …