RNA sequencing: new technologies and applications in cancer research

M Hong, S Tao, L Zhang, LT Diao, X Huang… - Journal of hematology & …, 2020 - Springer
Over the past few decades, RNA sequencing has significantly progressed, becoming a
paramount approach for transcriptome profiling. The revolution from bulk RNA sequencing …

Artificial intelligence in plant breeding

MA Farooq, S Gao, MA Hassan, Z Huang, A Rasheed… - Trends in Genetics, 2024 - cell.com
Harnessing cutting-edge technologies to enhance crop productivity is a pivotal goal in
modern plant breeding. Artificial intelligence (AI) is renowned for its prowess in big data …

Architecture and dynamics of meiotic chromosomes

SN Ur, KD Corbett - Annual Review of Genetics, 2021 - annualreviews.org
The specialized two-stage meiotic cell division program halves a cell's chromosome
complement in preparation for sexual reproduction. This reduction in ploidy requires that in …

Stage-resolved Hi-C analyses reveal meiotic chromosome organizational features influencing homolog alignment

W Zuo, G Chen, Z Gao, S Li, Y Chen, C Huang… - Nature …, 2021 - nature.com
During meiosis, chromosomes exhibit dramatic changes in morphology and intranuclear
positioning. How these changes influence homolog pairing, alignment, and recombination …

Chromosome organization in early meiotic prophase

C Grey, B De Massy - Frontiers in cell and developmental biology, 2021 - frontiersin.org
One of the most fascinating aspects of meiosis is the extensive reorganization of the genome
at the prophase of the first meiotic division (prophase I). The first steps of this reorganization …

A-MYB and BRDT-dependent RNA Polymerase II pause release orchestrates transcriptional regulation in mammalian meiosis

AK Alexander, EJ Rice, J Lujic, LE Simon… - Nature …, 2023 - nature.com
During meiotic prophase I, spermatocytes must balance transcriptional activation with
homologous recombination and chromosome synapsis, biological processes requiring …

The impact of chromosomal fusions on 3D genome folding and recombination in the germ line

C Vara, A Paytuví-Gallart, Y Cuartero… - Nature …, 2021 - nature.com
The spatial folding of chromosomes inside the nucleus has regulatory effects on gene
expression, yet the impact of genome reshuffling on this organization remains unclear. Here …

Epigenetic reprogramming in early animal development

Z Du, K Zhang, W Xie - Cold Spring Harbor Perspectives …, 2022 - cshperspectives.cshlp.org
Dramatic nuclear reorganization occurs during early development to convert terminally
differentiated gametes to a totipotent zygote, which then gives rise to an embryo. Aberrant …

PRGdb 4.0: an updated database dedicated to genes involved in plant disease resistance process

J Calle Garcia, A Guadagno… - Nucleic Acids …, 2022 - academic.oup.com
Abstract The Plant Resistance Genes database (PRGdb; http://prgdb. org/prgdb4/) has been
greatly expanded, keeping pace with the increasing amount of available knowledge and …

Chromosomics: Bridging the gap between genomes and chromosomes

JE Deakin, S Potter, R O'Neill, A Ruiz-Herrera… - Genes, 2019 - mdpi.com
The recent advances in DNA sequencing technology are enabling a rapid increase in the
number of genomes being sequenced. However, many fundamental questions in genome …