The locus coeruleus (LC), or 'blue spot', is a small nucleus located deep in the brainstem
that provides the far-reaching noradrenergic neurotransmitter system of the brain. This …

The locus coeruleus (LC), a small brainstem nucleus, is the primary source of the
neuromodulator norepinephrine (NE) in the brain. The LC receives input from widespread …

Noradrenaline released from the locus coeruleus (LC) is a ubiquitous neuromodulator,,–that
has been linked to multiple functions including arousal,,–, action and sensory gain,–, and …

Recent data demonstrate that noradrenergic neurons of the locus coeruleus (LC-NE) are
required for fear-induced suppression of feeding, but the role of endogenous LC-NE activity …

The claustrum (CLA) is a conspicuous subcortical structure interconnected with cortical and
subcortical regions. Its regional anatomy and cell-type-specific connections in the mouse …

The locus coeruleus (LC) is a critical node in the stress response, and its activation has
been shown to promote hypervigilance and anxiety-like behavior. This noradrenergic …

Evolutionarily, olfaction is one of the oldest senses and pivotal for an individual's health and
survival. The olfactory bulb (OB), as the first olfactory relay station in the brain, is known to …

Excitatory inputs drive burst firing of locus coeruleus (LC) noradrenaline (NA) neurons in
response to a variety of stimuli. Though a small number of glutamatergic LC afferents have …

In a constantly changing environment, organisms must track the current relationship
between actions and their specific consequences and use this information to guide decision …

As the primary source of norepinephrine (NE) in the brain, the locus coeruleus (LC)
regulates both arousal and stress responses1, 2. However, how local neuromodulatory …