Abstract The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer,
and such hyperactivation is generally associated with a poor clinical prognosis. In the …

The emergence of novel immunomodulatory cancer therapies over the last decade, above
all immune checkpoint blockade, has significantly advanced tumor treatment. For colorectal …

Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives
many of the cancer 'hallmarks' through downstream activation of the Janus kinase/signal …

Abstract The Signal Transducer and Activator of Transcription (STAT) family of proteins
consists of transcription factors that play a complex and essential role in the regulation of …

Signal transducer and activator of transcription (STAT) 1 is part of the Janus kinase
(JAK)/STAT signalling cascade and is best known for its essential role in mediating …

The janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling
pathway is associated with the regulation of essential cellular mechanisms, such as …

Accumulated studies have provided controversial evidences of the association between
signal transducer and activator of transcription proteins 3 (STAT3) expression and survival of …

STAT3 is considered to play an oncogenic role in several malignancies including lung
cancer; consequently, targeting STAT3 is currently proposed as therapeutic intervention …

Signal Transducer and Activator of Transcription 3 (STAT3) activation is frequently found in
non-small cell lung cancer (NSCLC) patient samples/cell lines and STAT3 inhibition in …

The Signal Transducer and Activator of Transcription (STAT) 3 and 5 proteins are activated
by many cytokine receptors to regulate specific gene expression and mitochondrial …