Molecular targeted therapy has revolutionized the landscape of cancer treatment due to
better therapeutic responses and less systemic toxicity. However, therapeutic resistance is a …

The fruit fly or Drosophila melanogaster has been used as a promising model organism in
genetics, developmental and behavioral studies as well as in the fields of neuroscience …

Epithelial sheets define organ architecture during development. Here, we employed an
iterative multiscale computational modeling and quantitative experimental approach to …

Morphogenetic programs coordinate cell signaling and mechanical interactions to shape
organs. In systems and synthetic biology, a key challenge is determining optimal cellular …

Multicellular model organisms, such as Drosophila melanogaster (fruit fly), are frequently
used in a myriad of biological research studies due to their biological significance and …

How a developing organ robustly coordinates the cellular mechanics and growth to reach a
final size and shape remains poorly understood. Through iterations between experiments …

Mechanosensitive Piezo channels regulate cell division, cell extrusion, and cell death.
However, systems-level functions of Piezo in regulating organogenesis remain poorly …

Microfluidic devices provide a platform for analyzing both natural and synthetic multicellular
systems. Currently, substantial capital investment and expertise are required for creating …

Regenerative retinal therapies have introduced progenitor cells to replace dysfunctional or
injured neurons and regain visual function. While contemporary cell replacement therapies …

The evolution of laser technologies and the invention of ultrashort laser pulses have resulted
in a sharp jump in laser applications in life sciences. Developmental biology is no exception …