Non-coding RNAs as direct and indirect modulators of epigenetic regulation

VJ Peschansky, C Wahlestedt - Epigenetics, 2014 - Taylor & Francis
Epigenetic regulation of gene expression is an increasingly well-understood concept that
explains much of the contribution of an organism's environment and experience to its …

Genetics of circadian rhythms in Mammalian model organisms

PL Lowrey, JS Takahashi - Advances in genetics, 2011 - Elsevier
The mammalian circadian system is a complex hierarchical temporal network which is
organized around an ensemble of uniquely coupled cells comprising the principal circadian …

Tumor suppressors BTG1 and BTG2: Beyond growth control

L Yuniati, B Scheijen, LT van der Meer… - Journal of cellular …, 2019 - Wiley Online Library
Since the identification of B‐cell translocation gene 1 (BTG1) and BTG2 as antiproliferation
genes more than two decades ago, their protein products have been implicated in a variety …

MicroRNAs in neuronal function and dysfunction

HI Im, PJ Kenny - Trends in neurosciences, 2012 - cell.com
MicroRNAs (miRNAs) are small noncoding RNA transcripts expressed throughout the brain
that can regulate neuronal gene expression at the post-transcriptional level. Here, we …

Circadian rhythm disruption in cancer biology

C Savvidis, M Koutsilieris - Molecular medicine, 2012 - Springer
Circadian rhythms show universally a 24-h oscillation pattern in metabolic, physiological
and behavioral functions of almost all species. This pattern is due to a fundamental …

Adult-specific functions of animal microRNAs

K Sun, EC Lai - Nature reviews genetics, 2013 - nature.com
Abstract MicroRNAs (miRNAs) are~ 22 nt RNAs that coordinate vast regulatory networks in
animals and thereby influence myriad processes. This Review examines evidence that …

miR-212/132 expression and functions: within and beyond the neuronal compartment

A Wanet, A Tacheny, T Arnould… - Nucleic acids …, 2012 - academic.oup.com
During the last two decades, microRNAs (miRNAs) emerged as critical regulators of gene
expression. By modulating the expression of numerous target mRNAs mainly at the post …

De-repression of FOXO3a death axis by microRNA-132 and-212 causes neuronal apoptosis in Alzheimer's disease

HKA Wong, T Veremeyko, N Patel… - Human molecular …, 2013 - academic.oup.com
Alzheimer's disease (AD) is a multifactorial and fatal neurodegenerative disorder for which
the mechanisms leading to profound neuronal loss are incompletely recognized. MicroRNAs …

[HTML][HTML] MicroRNAs shape the neuronal landscape

E McNeill, D Van Vactor - Neuron, 2012 - cell.com
The nervous system equips us with capability to adapt to many conditions and
circumstances. We rely on an armamentarium of intricately formed neural circuits for many of …

An epigenetic framework for neurodevelopmental disorders: from pathogenesis to potential therapy

MJ Millan - Neuropharmacology, 2013 - Elsevier
Neurodevelopmental disorders (NDDs) are characterized by aberrant and delayed early-life
development of the brain, leading to deficits in language, cognition, motor behaviour and …